Abstract
A combination of two drugs afforded remarkable protection from intestinal neoplasia in APC(Min/+) mice, a murine model of human familial adenomatous polyposis (FAP). One of the drugs was sulindac, a prototypical non-steroidal anti-inflammatory drug with established chemopreventative activity. The second drug was EKI-569, a newly developed, irreversible inhibitor of the epidermal growth factor receptor kinase. Although 100% of the untreated APC(Min/+) mice developed ~20 polyps, nearly half the mice treated with these two agents developed no polyps at all. These results suggest a powerful strategy for the chemoprevention of human colonic neoplasia.
Original language | English (US) |
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Pages (from-to) | 1024-1028 |
Number of pages | 5 |
Journal | Nature medicine |
Volume | 6 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2000 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology