Combination treatment with human adipose tissue stem cellderived exosomes and fractional co2 laser for acne scars: A 12-week prospective, double-blind, randomized, split-face study

Hyuck Hoon Kwon, Steven Hoseong Yang, Joon Lee, Byung Cheol Park, Kui Young Park, Jae Yoon Jung, Youin Bae, Gyeong Hun Park

Research output: Contribution to journalArticlepeer-review

Abstract

A variety of applications of human adipose tissue stem cell-derived exosomes have been suggested as novel cell-free therapeutic strategies in the regenerative and aesthetic medical fields. This study evaluated the clinical efficacy and safety of adipose tissue stem cell-derived exosomes as an adjuvant therapy after application of fractional CO2 laser for acne scars. A 12-week prospective, double-blind, randomized, split-face trial was performed. A total of 25 patients received three consecutive treatment sessions of fractional CO2 laser to the whole face, with a follow-up evaluation. Postlaser treatment regimens were applied; for each patient, one side of the face was treated with adipose tissue stem cell-derived exosomes gel and the other side was treated with control gel. Adipose tissue stem cell-derived exosomes-treated sides had achieved a significantly greater improvement than the control sides at the final follow-up visit (percentage reduction in échelle d’évaluation clinique des cicatrices d’acné scores: 32.5 vs 19.9%, p < 0.01). Treatment-related erythema was milder, and post-treatment downtime was shorter on the human adipose tissue stem cell-derived exosomes-treated side. In conclusion, the combined use of this novel material with resurfacing devices would provide synergistic effects on both the efficacy and safety of atrophic acne scar treatments.

Original languageEnglish (US)
Article numberadv00310
Pages (from-to)1-8
Number of pages8
JournalActa Dermato-Venereologica
Volume100
Issue number18
DOIs
StatePublished - 2020

Keywords

  • Acne scar
  • Adipose tissue stem cell-derived exosomes
  • Fractional laser

ASJC Scopus subject areas

  • Dermatology

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