Combination therapy for invasive aspergillosis: Controversies and conclusions

Haran T. Schlamm, Kieren A. Marr

Research output: Contribution to journalArticle

Abstract

Historically poor outcomes have generated many efforts toward improving outcomes of invasive pulmonary aspergillosis in immunosuppressed hosts, by improving prevention strategies, use of early diagnostics, and employing new antifungals, including combinations of drugs. The latter approach is supported by theoretical benefits in both the antimicrobial activity and pharmacologic properties of drugs, with in vitro and animal studies suggesting potential utility. Because drug combinations can also increase toxicities, interactions, and costs, demonstrating therapeutic effects in clinical trials is imperative. Here, clinical data evaluating combination antifungal therapy for aspergillosis are reviewed. Results to date suggest potential benefit of antifungal combinations, especially those including azoles and echinocandins, but conclusions are not definitive. This important topic warrants further study.

Original languageEnglish (US)
Article numberA004
Pages (from-to)130-134
Number of pages5
JournalCurrent Fungal Infection Reports
Volume9
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • Antifungal therapy
  • Aspergillosis
  • Combination therapy
  • Fungal infections

ASJC Scopus subject areas

  • Infectious Diseases

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