Combination percutaneous and intraarterial therapy for the treatment of hepatocellular carcinoma: A review

Research output: Contribution to journalReview article


Transcatheter arterial chemoembolization (TACE) and percutaneous ablation therapies have been shown to provide effective therapy and afford survival prolongation for patients with unresectable hepatocellular carcinoma (HCC). Both treatments, however, have inherent limitations that restrict their benefit; TACE is not a curative therapy and ablation efficacy is significantly limited by lesion size. Current treatment strategies aim to combine intraarterial and percutaneous liver-directed therapies synergistically to improve tumor response, and by extension improve patient survival. This article reviews the current literature on combination treatments, and examines the circumstances in which therapeutic combinations would improve tumor response and patient survival.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalSeminars in Interventional Radiology
Issue number3
StatePublished - Aug 30 2010



  • Hepatocellular carcinoma
  • chemoembolization
  • cryoablation
  • microwave
  • radiofrequency ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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