Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia

Li Feng Zhang, Darren Qian Cheng Tan, Anand D. Jeyasekharan, Wen Son Hsieh, Anh Son Ho, Koji Ichiyama, Min Ye, Brendan Pang, Kenji Ohba, Xin Liu, Sanjay de Mel, Bui Khac Cuong, Wee Joo Chng, Akihide Ryo, Youichi Suzuki, Khay Guan Yeoh, Nguyen Linh Toan, Naoki Yamamoto

Research output: Contribution to journalArticle

Abstract

Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.

Original languageEnglish (US)
Pages (from-to)272-280
Number of pages9
JournalCancer Letters
Volume354
Issue number2
DOIs
StatePublished - Nov 28 2014

Keywords

  • Acute myeloid leukemia
  • Measles virus
  • Mumps virus
  • Oncolytic virus

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Zhang, L. F., Tan, D. Q. C., Jeyasekharan, A. D., Hsieh, W. S., Ho, A. S., Ichiyama, K., Ye, M., Pang, B., Ohba, K., Liu, X., de Mel, S., Cuong, B. K., Chng, W. J., Ryo, A., Suzuki, Y., Yeoh, K. G., Toan, N. L., & Yamamoto, N. (2014). Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia. Cancer Letters, 354(2), 272-280. https://doi.org/10.1016/j.canlet.2014.08.034