Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia

Li Feng Zhang; Darren Qian Cheng Tan; Anand D. Jeyasekharan; Wen Son Hsieh; Anh Son Ho; Koji Ichiyama; Min Ye; Brendan Pang; Kenji Ohba; Xin Liu; Sanjay de Mel; Bui Khac Cuong; Wee Joo Chng; Akihide Ryo; Youichi Suzuki; Khay Guan Yeoh; Nguyen Linh Toan; Naoki Yamamoto

doi:10.1016/j.canlet.2014.08.034

Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia

Li Feng Zhang, Darren Qian Cheng Tan, Anand D. Jeyasekharan, Wen Son Hsieh, Anh Son Ho, Koji Ichiyama, Min Ye, Brendan Pang, Kenji Ohba, Xin Liu, Sanjay de Mel, Bui Khac Cuong, Wee Joo Chng, Akihide Ryo, Youichi Suzuki, Khay Guan Yeoh, Nguyen Linh Toan, Naoki Yamamoto

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.

Original language	English (US)
Pages (from-to)	272-280
Number of pages	9
Journal	Cancer Letters
Volume	354
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2014.08.034
State	Published - Nov 28 2014

Keywords

Acute myeloid leukemia
Measles virus
Mumps virus
Oncolytic virus

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/j.canlet.2014.08.034

Cite this

Zhang, L. F., Tan, D. Q. C., Jeyasekharan, A. D., Hsieh, W. S., Ho, A. S., Ichiyama, K., Ye, M., Pang, B., Ohba, K., Liu, X., de Mel, S., Cuong, B. K., Chng, W. J., Ryo, A., Suzuki, Y., Yeoh, K. G., Toan, N. L., & Yamamoto, N. (2014). Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia. Cancer Letters, 354(2), 272-280. https://doi.org/10.1016/j.canlet.2014.08.034

Zhang, LF, Tan, DQC, Jeyasekharan, AD, Hsieh, WS, Ho, AS, Ichiyama, K, Ye, M, Pang, B, Ohba, K, Liu, X, de Mel, S, Cuong, BK, Chng, WJ, Ryo, A, Suzuki, Y, Yeoh, KG, Toan, NL & Yamamoto, N 2014, 'Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia', Cancer Letters, vol. 354, no. 2, pp. 272-280. https://doi.org/10.1016/j.canlet.2014.08.034

@article{ad1ee50bcd954d239e85dc1de33e8eb1,

title = "Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia",

abstract = "Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.",

keywords = "Acute myeloid leukemia, Measles virus, Mumps virus, Oncolytic virus",

author = "Zhang, {Li Feng} and Tan, {Darren Qian Cheng} and Jeyasekharan, {Anand D.} and Hsieh, {Wen Son} and Ho, {Anh Son} and Koji Ichiyama and Min Ye and Brendan Pang and Kenji Ohba and Xin Liu and {de Mel}, Sanjay and Cuong, {Bui Khac} and Chng, {Wee Joo} and Akihide Ryo and Youichi Suzuki and Yeoh, {Khay Guan} and Toan, {Nguyen Linh} and Naoki Yamamoto",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Ireland Ltd.",

year = "2014",

month = nov,

day = "28",

doi = "10.1016/j.canlet.2014.08.034",

language = "English (US)",

volume = "354",

pages = "272--280",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells

T2 - Special focus on acute myeloid leukemia

AU - Zhang, Li Feng

AU - Tan, Darren Qian Cheng

AU - Jeyasekharan, Anand D.

AU - Hsieh, Wen Son

AU - Ho, Anh Son

AU - Ichiyama, Koji

AU - Ye, Min

AU - Pang, Brendan

AU - Ohba, Kenji

AU - Liu, Xin

AU - de Mel, Sanjay

AU - Cuong, Bui Khac

AU - Chng, Wee Joo

AU - Ryo, Akihide

AU - Suzuki, Youichi

AU - Yeoh, Khay Guan

AU - Toan, Nguyen Linh

AU - Yamamoto, Naoki

PY - 2014/11/28

Y1 - 2014/11/28

N2 - Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.

AB - Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.

KW - Acute myeloid leukemia

KW - Measles virus

KW - Mumps virus

KW - Oncolytic virus

UR - http://www.scopus.com/inward/record.url?scp=84908007836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908007836&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2014.08.034

DO - 10.1016/j.canlet.2014.08.034

M3 - Article

C2 - 25193462

AN - SCOPUS:84908007836

SN - 0304-3835

VL - 354

SP - 272

EP - 280

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this