Combination immunotherapy for cancer: Synergistic antitumor interactions of interleukin-2, alfa interferon, and tumor-infiltrating lymphocytes

Steven A. Rosenberg, Susan L. Schwarz, Paul J. Spiess

Research output: Contribution to journalArticle


Attempts have been made to design optimal strategies for the immunotherapy of established tumors. In micebearing pulmonary metastases from sarcomas, a substantial therapeutic synergy was seen when bothinterleukin-2(IL-2) and alfa interferon(α-IFN) were administered compared with the effect of either agentgiven alone. This synergy was dependent on Lyt-2+T cells, since therapeutic effects were abrogated in Lyt-2 depleted mice. The αIFN and IL-2 combination was also synergistic with tumor-infiltrating lymphocytes inmediating the reduction of established lung metastases. These experiments demonstrate that combination immunotherapy can result in substantial reduction of established metastatic deposits and provide a rationale for the application of this treatment to patients with advanced cancer. [J National Cancer Inst 1988;80:1393-1397]

Original languageEnglish (US)
Pages (from-to)1393-1397
Number of pages5
JournalJournal of the National Cancer Institute
Issue number17
StatePublished - Nov 2 1988


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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