Combat Wound Initiative program.

Alexander Stojadinovic, Eric Elster, Benjamin K. Potter, Thomas A. Davis, Doug K. Tadaki, Trevor S. Brown, Stephen Ahlers, Christopher E. Attinger, Romney C. Andersen, David Burris, Jose Centeno, Hunter Champion, David R. Crumbley, John Denobile, Michael Duga, James R. Dunne, John Eberhardt, William J. Ennis, Jonathan A. Forsberg, Jason HawksworthThomas S. Helling, Gerald S. Lazarus, Stephen M. Milner, Florabel G. Mullick, Christopher R. Owner, Paul F. Pasquina, Chirag R. Patel, George E. Peoples, Aviram Nissan, Michael Ring, Glenn D. Sandberg, Wolfgang Schaden, Gregory S. Schultz, Tom Scofield, Scott B. Shawen, Forest R. Sheppard, James P. Stannard, Peter J. Weina, Jonathan M. Zenilman

Research output: Contribution to journalReview article

Abstract

The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalUnknown Journal
Volume175
Issue number7 Suppl
StatePublished - Jul 2010

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Stojadinovic, A., Elster, E., Potter, B. K., Davis, T. A., Tadaki, D. K., Brown, T. S., Ahlers, S., Attinger, C. E., Andersen, R. C., Burris, D., Centeno, J., Champion, H., Crumbley, D. R., Denobile, J., Duga, M., Dunne, J. R., Eberhardt, J., Ennis, W. J., Forsberg, J. A., ... Zenilman, J. M. (2010). Combat Wound Initiative program. Unknown Journal, 175(7 Suppl), 18-24.