Abstract
A column-switch high performance liquid chromatography method for the analysis of 4 mL of plasma is described with six examples of chromatography of [11C]-labeled positron-emission tomography imaging agents. Complete extraction of all but the most polar metabolites by the reverse phase capture column is achieved by disruption of plasma protein binding by 8 M urea. (C) 2000 Elsevier Science Inc.
Original language | English (US) |
---|---|
Pages (from-to) | 627-630 |
Number of pages | 4 |
Journal | Nuclear Medicine and Biology |
Volume | 27 |
Issue number | 6 |
DOIs | |
State | Published - 2000 |
Keywords
- Column-switch
- HPLC
- PET
- Plasma
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research