Colorectal carcinoma in black and white race

William F. Anderson, Asad Umar, Otis W. Brawley

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Worldwide, colorectal carcinoma (CRC) varies by race-ethnicity. The highest incidence occurs in whites of European descent. Rates in blacks of South Africa are much lower, but rise with migration to westernized countries, i.e. African Americans (blacks) in the US. In the US, CRC age-specific incidence rates increased dramatically with biologic aging for black and white men and women. For all ages, rates were slightly higher for black than for whites. Among whites, overall annual rates peaked in the 1980s then declined. Stage- and subsite-specific rate shifts suggested earlier detection of cancers through screening, particularly in the distal colon. Blacks have not experienced the same stage- and subsite temporal shifts, which were observed in whites. CRC racial differences have been attributed to biologic and/or non-biologic factors as well as to routine screening patterns. Racial variations demonstrate the need for a more comprehensive understanding of colorectal carcinogenesis, epidemiology, and colorectal screening patterns for low- and high-risk populations.

Original languageEnglish (US)
Pages (from-to)67-82
Number of pages16
JournalCancer and Metastasis Reviews
Issue number1
StatePublished - Mar 1 2003
Externally publishedYes


  • Chromosomal instability
  • Colorectal cancer screening
  • Colorectal carcinoma
  • Genetic susceptibility polymorphisms
  • Microsatellite instability
  • Racial variations

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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