Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

J. W R Mulder; Miguel Sewnath; Gja Offerhaus; St Pals; J. Oosting; Pm Kruyt; Wf Weidema; Ca Seldenrijk

doi:10.1016/S0140-6736(94)90290-9

Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

J. W R Mulder, Miguel Sewnath, Gja Offerhaus, St Pals, J. Oosting, Pm Kruyt, Wf Weidema, Ca Seldenrijk

Research output: Contribution to journal › Article › peer-review

298 Scopus citations

Abstract

CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients.

Original language	English (US)
Pages (from-to)	1470-1472
Number of pages	3
Journal	The Lancet
Volume	344
Issue number	8935
DOIs	https://doi.org/10.1016/S0140-6736(94)90290-9
State	Published - Nov 26 1994
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(94)90290-9

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title = "Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins",

abstract = "CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients.",

author = "Mulder, {J. W R} and Miguel Sewnath and Gja Offerhaus and St Pals and J. Oosting and Pm Kruyt and Wf Weidema and Ca Seldenrijk",

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T1 - Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

AU - Mulder, J. W R

AU - Sewnath, Miguel

AU - Offerhaus, Gja

AU - Pals, St

AU - Oosting, J.

AU - Kruyt, Pm

AU - Weidema, Wf

AU - Seldenrijk, Ca

PY - 1994/11/26

Y1 - 1994/11/26

N2 - CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients.

AB - CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients.

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ER -

Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

Abstract

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