Colonization and infection with Trichosporon species in the immunosuppressed host

Helen M. Haupt, William G. Merz, William E. Beschomer, William P. Vaughan, Rein Saral

Research output: Contribution to journalArticle

Abstract

Trichosporon beigelii and Trichosporon capitatum have recently been recognized as systemic pathogens in the immunosuppressed host. We studied the incidence of colonization and systemic infection with these organisms in 353 highly immunocompromised patients over a 37-month period. Thirteen patients (3.7%) had positive surveillance cultures for Trichosporon species in stool, skin, or urine. Three of the 13 patients developed systemic infections after having positive surveillance cultures. In two of these three patients, urine cultures were positive near the time of systemic infection. The route of entry appeared to have been enteric in two patients and cutaneous in one patient. Both colonizing and infecting organisms showed in vitro susceptibility to amphotericin B and nystatin. This study suggests that positive surveillance cultures for Trichosporon species may correlate with systemic infection in the severely immunocompromised patient and that repeated positive urine cultures may indicate dissemination.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalUnknown Journal
Volume147
Issue number2
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Colonization and infection with Trichosporon species in the immunosuppressed host'. Together they form a unique fingerprint.

  • Cite this

    Haupt, H. M., Merz, W. G., Beschomer, W. E., Vaughan, W. P., & Saral, R. (1983). Colonization and infection with Trichosporon species in the immunosuppressed host. Unknown Journal, 147(2), 199-203. https://doi.org/10.1093/infdis/147.2.199