Colonisation endpoints in Streptococcus pneumoniae vaccine trials

Kari Auranen, Hanna Rinta-Kokko, David Goldblatt, Hanna Nohynek, Katherine L. O'Brien, Catherine Satzke, Birgit Simell, Antti Tanskanen, Helena Käyhty

Research output: Contribution to journalReview article

Abstract

Evaluating vaccine efficacy for protection against colonisation (VEcol) with bacterial pathogens is an area of growing interest. In this article, we consider estimation of VEcol for colonisation with Streptococcus pneumoniae (the pneumococcus). Colonisation is a common, recurrent and multi-type endpoint that requires both careful definition of the vaccine efficacy parameter and the corresponding method of estimation. We review recent developments in the area and provide practical guidelines for choosing the estimand and the estimation method in trials with a colonisation endpoint. We concentrate on methods that are based on a cross-sectional study design, in which only one nasopharyngeal sample is obtained per study subject.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalVaccine
Volume32
Issue number1
DOIs
StatePublished - Dec 17 2013

Keywords

  • Nasopharyngeal colonisation
  • Pneumococcus
  • Trial endpoint
  • Vaccine efficacy

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Auranen, K., Rinta-Kokko, H., Goldblatt, D., Nohynek, H., O'Brien, K. L., Satzke, C., Simell, B., Tanskanen, A., & Käyhty, H. (2013). Colonisation endpoints in Streptococcus pneumoniae vaccine trials. Vaccine, 32(1), 153-158. https://doi.org/10.1016/j.vaccine.2013.08.061