TY - JOUR
T1 - Colonic perforation
T2 - An unusual complication of therapy with high‐dose lnterleukin‐2
AU - Schwartzentruber, Douglas
AU - Lotze, Michael T.
AU - Rosenberg, Steven A.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1988/12/1
Y1 - 1988/12/1
N2 - The majority (85%) of patients receiving high dose Interleukin‐2 (IL‐2) experience gastrointestinal side effects, namely nausea, vomiting and diarrhea. In this article we describe four cancer patients that developed localized necrosis or perforation of the colon during IL‐2 treatment. They represent 1.3% of patients (n = 315) or 0.9% of treatment courses (n = 452). All underwent surgical intervention and survived to leave the hospital. No common etiologic factor was apparent. Two patients were subsequently retreated with IL‐2 without complication. Localized colonic necrosis or perforation is a rare complication associated with high dose IL‐2 treatments. Aggressive surgical intervention is advocated and retreatment following recovery is safe.
AB - The majority (85%) of patients receiving high dose Interleukin‐2 (IL‐2) experience gastrointestinal side effects, namely nausea, vomiting and diarrhea. In this article we describe four cancer patients that developed localized necrosis or perforation of the colon during IL‐2 treatment. They represent 1.3% of patients (n = 315) or 0.9% of treatment courses (n = 452). All underwent surgical intervention and survived to leave the hospital. No common etiologic factor was apparent. Two patients were subsequently retreated with IL‐2 without complication. Localized colonic necrosis or perforation is a rare complication associated with high dose IL‐2 treatments. Aggressive surgical intervention is advocated and retreatment following recovery is safe.
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U2 - 10.1002/1097-0142(19881201)62:11<2350::AID-CNCR2820621116>3.0.CO;2-S
DO - 10.1002/1097-0142(19881201)62:11<2350::AID-CNCR2820621116>3.0.CO;2-S
M3 - Article
C2 - 3263182
AN - SCOPUS:0023798711
SN - 0008-543X
VL - 62
SP - 2350
EP - 2353
JO - Cancer
JF - Cancer
IS - 11
ER -