Colonic perforation: An unusual complication of therapy with high-dose interleukin-2

D. Schwartzentruber, M. T. Lotze, S. A. Rosenberg

Research output: Contribution to journalArticle

Abstract

The majority (85%) of patients receiving high dose Interleukin-2 (IL-2) experience gastrointestinal side effects, namely nausea, vomiting and diarrhea. In this article we describe four cancer patients that developed localized necrosis or perforation of the colon during IL-2 treatment. They represent 1.3% of patients (n = 315) or 0.9% of treatment courses (n = 452). All underwent surgical intervention and survived to leave the hospital. No common etiologic factor was apparent. Two patients were subsequently retreated with IL-2 without complication. Localized colonic necrosis or perforation is a rare complication associated with high dose IL-2 treatments. Aggressive surgical intervention is advocated and retreatment following recovery is safe.

Original languageEnglish (US)
Pages (from-to)2350-2353
Number of pages4
JournalCancer
Volume62
Issue number11
StatePublished - 1988
Externally publishedYes

Fingerprint

Interleukin-2
Necrosis
Retreatment
Therapeutics
Nausea
Vomiting
Diarrhea
Colon
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Schwartzentruber, D., Lotze, M. T., & Rosenberg, S. A. (1988). Colonic perforation: An unusual complication of therapy with high-dose interleukin-2. Cancer, 62(11), 2350-2353.

Colonic perforation : An unusual complication of therapy with high-dose interleukin-2. / Schwartzentruber, D.; Lotze, M. T.; Rosenberg, S. A.

In: Cancer, Vol. 62, No. 11, 1988, p. 2350-2353.

Research output: Contribution to journalArticle

Schwartzentruber, D, Lotze, MT & Rosenberg, SA 1988, 'Colonic perforation: An unusual complication of therapy with high-dose interleukin-2', Cancer, vol. 62, no. 11, pp. 2350-2353.
Schwartzentruber D, Lotze MT, Rosenberg SA. Colonic perforation: An unusual complication of therapy with high-dose interleukin-2. Cancer. 1988;62(11):2350-2353.
Schwartzentruber, D. ; Lotze, M. T. ; Rosenberg, S. A. / Colonic perforation : An unusual complication of therapy with high-dose interleukin-2. In: Cancer. 1988 ; Vol. 62, No. 11. pp. 2350-2353.
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