Coloboma of Optic Nerve Associated With Serous Maculopathy: A Clinicopathologic Correlative Study

Charles Chia Lee Lin, Mark O M Tso, Charles M. Vygantas

Research output: Contribution to journalArticle

Abstract

• A rhesus monkey with a congenital coloboma of the optic nerve head associated with serous macular detachment underwent intravenous (IV), intrathecal, and retrobulbar fluorescein angiography. No fluorescein leaked beneath the serous detachment after IV or intrathecal injection, although the retrobulbar injection caused a bolus to extravasate from the margin of the optic nerve coloboma, drifting toward the macular region temporally. Histopathologically, glial tissue replaced optic nerve axonal bundles in the temporal coloboma. The intermediary tissue of Kuhnt was disrupted, and fluid from the retrobulbar space diffused into the sub-retinal space temporally, where a localized retinal detachment extended from the optic nerve to the macula. Subretinal fluid in the macula associated with optic nerve coloboma might derive from (1) fluid perfusing into the retrobulbar space from surrounding orbital tissue, (2) peripapillary choriocapillaris, or (3) CSF.

Original languageEnglish (US)
Pages (from-to)1651-1654
Number of pages4
JournalArchives of Ophthalmology
Volume102
Issue number11
DOIs
StatePublished - 1984
Externally publishedYes

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Optic Nerve
Subretinal Fluid
Coloboma
Spinal Injections
Fluorescein Angiography
Optic Disk
Retinal Detachment
Macaca mulatta
Fluorescein
Intravenous Injections
Neuroglia
Injections
Coloboma of optic nerve

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Coloboma of Optic Nerve Associated With Serous Maculopathy : A Clinicopathologic Correlative Study. / Lin, Charles Chia Lee; Tso, Mark O M; Vygantas, Charles M.

In: Archives of Ophthalmology, Vol. 102, No. 11, 1984, p. 1651-1654.

Research output: Contribution to journalArticle

Lin, Charles Chia Lee ; Tso, Mark O M ; Vygantas, Charles M. / Coloboma of Optic Nerve Associated With Serous Maculopathy : A Clinicopathologic Correlative Study. In: Archives of Ophthalmology. 1984 ; Vol. 102, No. 11. pp. 1651-1654.
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