Collaterals: An important determinant of prolonged ischemic penumbra versus rapid cerebral infarction?

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous tissue plasminogen activator is the mainstay for the treatment of acute ischemic stroke in patients presenting within 4.5 h of symptom onset. Studies have demonstrated that treating patients early leads to improved long-term outcomes. MR imaging currently allows quantification of the ischemic penumbra in order to better identify individuals most likely to benefit from intervention, irrespective of "time last seen normal." Its increasing use in clinical practice has demonstrated individual differences in rate of infarction. One explanation for this variability is a difference in collateral blood flow. We report two cases that highlight the individual variability of infarction rate, and discuss potential underlying mechanisms that may influence treatment decisions and outcomes.

Original languageEnglish (US)
Article number208
JournalFrontiers in Neurology
Volume5
Issue numberOCT
DOIs
StatePublished - 2014

Keywords

  • Collaterals
  • Intra-arterial thrombolysis
  • Ischemic stroke
  • Penumbra
  • Recovery

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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