Collagen fibril D-period may change as a function of strain and location in ligament

Udita Kukreti, Stephen M. Belkoff

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to determine if the characteristic banding pattern (D-period) of collagen fibrils from rabbit medial collateral ligaments changes as a function of gross ligament strain and, if so, whether the changes are location dependent (insertion versus midsubstance). Femur-medial collateral ligament-tibia complexes were strained to 0, 8, or 12% and immediately chemically fixed in situ. Samples were taken from the medial collateral ligament midsubstance and bony insertions, and prepared for and observed under a transmission electron microscope. D-period length was measured and found to increase (albeit not significantly so, p=0.1) as a function of gross strain for samples obtained from the insertion sites but not for samples obtained from the ligament midsubstance. Results suggested that ligament strains are inhomogeneous at the ultrastructural level. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)1569-1574
Number of pages6
JournalJournal of Biomechanics
Volume33
Issue number12
DOIs
StatePublished - Dec 1 2000

Keywords

  • Collagen
  • D-period
  • Ligament
  • Strain
  • Ultrastructure

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

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