Collagen and its remodelling in ruminant follicles/corpora lutea

Y. Zhao, M. R. Luck

Research output: Contribution to journalArticlepeer-review


Ovarian function, pregnancy and consequently the success of reproduction, depend on a series of ovarian tissue cycles. The differentiation of endocrine cells is accompanied by synthesis, destruction and remodelling of the extracellular matrix (ECM). Components of the ECM contribute to the regulation of endocrine cell differentiation and these cells are themselves sources of the ECM proteins, enzymes and regulators which determine tissue structure. In this paper, we focus on collagen and its remodelling in the ruminant ovary to ask the following three questions: what is being remodelled?, how is the matrix protein remodelled? and what controls the remodelling process? Sheep with prostaglandin- synchronised cycles were used to provide tissue for analysis at known stages of the ovarian cycle. The gene expression and protein distribution collagen types I and IV in the ovary varied with tissue region and developmental stage of the ovarian tissue cycle. Metalloproteinase (MMP) activity, which plays a key role in matrix turnover and remodelling, is high at certain stages of the cycle, as is the expression of its principal regulator, tissue inhibitor of metalloproteinase 1 (TIMP-1). The precise regulation of MMP by TIMP is likely to be crucial to the correct functioning of tissues during the cycle and into pregnancy. Collagen remodelling is therefore a potentially important site for the occurrence of natural dysfunction leading to infertility, and a potential target in the manipulation of ovarian function.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalAdvances in Contraceptive Delivery Systems
Issue number1-2
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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