Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants

Seymour Lederberg; Gail Stetten

doi:10.1126/science.168.3930.485

Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants

Seymour Lederberg, Gail Stetten

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N- methylcolchicine) in nutrient medium. Cell growth continues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.

Original language	English (US)
Pages (from-to)	485-487
Number of pages	3
Journal	Science
Volume	168
Issue number	3930
DOIs	https://doi.org/10.1126/science.168.3930.485
State	Published - 1970
Externally published	Yes

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title = "Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants",

abstract = "Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N- methylcolchicine) in nutrient medium. Cell growth continues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.",

author = "Seymour Lederberg and Gail Stetten",

year = "1970",

doi = "10.1126/science.168.3930.485",

language = "English (US)",

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T1 - Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants

AU - Lederberg, Seymour

AU - Stetten, Gail

PY - 1970

Y1 - 1970

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AB - Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N- methylcolchicine) in nutrient medium. Cell growth continues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.

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Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants

Abstract

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