Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants

Seymour Lederberg, Gail Stetten

Research output: Contribution to journalArticle

Abstract

Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N- methylcolchicine) in nutrient medium. Cell growth continues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.

Original languageEnglish (US)
Pages (from-to)485-487
Number of pages3
JournalScience
Volume168
Issue number3930
StatePublished - 1970
Externally publishedYes

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Demecolcine
Schizosaccharomyces
Antimitotic Agents
Growth
Cell Division
Food

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Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants. / Lederberg, Seymour; Stetten, Gail.

In: Science, Vol. 168, No. 3930, 1970, p. 485-487.

Research output: Contribution to journalArticle

Lederberg, S & Stetten, G 1970, 'Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants', Science, vol. 168, no. 3930, pp. 485-487.
Lederberg, Seymour ; Stetten, Gail. / Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants. In: Science. 1970 ; Vol. 168, No. 3930. pp. 485-487.
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