Coinfection with zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host

Barbara Aparecida Chaves, Alessandra Silva Orfano, Paula Monalisa Nogueira, Nilton Barnabe Rodrigues, Thais Bonifácio Campolina, Rafael Nacif-Pimenta, Ana Clara Araújo Machado Pires, Ademir Bentes Vieira Júnior, Andréia Da Costa Paz, Evelyn Beatriz Da Costa Vaz, Maria Das Graças Vale Barbosa Guerra, Breno Melo Silva, Fabrício Freire De Melo, Douglas Norris, Marcus Vinícius Guimarães De Lacerda, Paulo Filemon Paolucci Pimenta, Nágila Francinete Costa Secundino

Research output: Contribution to journalArticle

Abstract

Background Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.

Original languageEnglish (US)
Pages (from-to)563-571
Number of pages9
JournalJournal of Infectious Diseases
Volume218
Issue number4
DOIs
StatePublished - Jul 13 2018

Fingerprint

Dengue Virus
Bites and Stings
Coinfection
Vertebrates
Arboviruses
Amazona
Aedes
Culicidae
Mental Competency
Brazil
Zika Virus
Public Health
Population

Keywords

  • Aedes aegypti
  • Coinfection
  • dengue virus
  • preferential transmission
  • vector bite
  • Zika virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Chaves, B. A., Orfano, A. S., Nogueira, P. M., Rodrigues, N. B., Campolina, T. B., Nacif-Pimenta, R., ... Secundino, N. F. C. (2018). Coinfection with zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host. Journal of Infectious Diseases, 218(4), 563-571. https://doi.org/10.1093/infdis/jiy196

Coinfection with zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host. / Chaves, Barbara Aparecida; Orfano, Alessandra Silva; Nogueira, Paula Monalisa; Rodrigues, Nilton Barnabe; Campolina, Thais Bonifácio; Nacif-Pimenta, Rafael; Pires, Ana Clara Araújo Machado; Júnior, Ademir Bentes Vieira; Paz, Andréia Da Costa; Vaz, Evelyn Beatriz Da Costa; Guerra, Maria Das Graças Vale Barbosa; Silva, Breno Melo; De Melo, Fabrício Freire; Norris, Douglas; De Lacerda, Marcus Vinícius Guimarães; Pimenta, Paulo Filemon Paolucci; Secundino, Nágila Francinete Costa.

In: Journal of Infectious Diseases, Vol. 218, No. 4, 13.07.2018, p. 563-571.

Research output: Contribution to journalArticle

Chaves, BA, Orfano, AS, Nogueira, PM, Rodrigues, NB, Campolina, TB, Nacif-Pimenta, R, Pires, ACAM, Júnior, ABV, Paz, ADC, Vaz, EBDC, Guerra, MDGVB, Silva, BM, De Melo, FF, Norris, D, De Lacerda, MVG, Pimenta, PFP & Secundino, NFC 2018, 'Coinfection with zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host', Journal of Infectious Diseases, vol. 218, no. 4, pp. 563-571. https://doi.org/10.1093/infdis/jiy196
Chaves, Barbara Aparecida ; Orfano, Alessandra Silva ; Nogueira, Paula Monalisa ; Rodrigues, Nilton Barnabe ; Campolina, Thais Bonifácio ; Nacif-Pimenta, Rafael ; Pires, Ana Clara Araújo Machado ; Júnior, Ademir Bentes Vieira ; Paz, Andréia Da Costa ; Vaz, Evelyn Beatriz Da Costa ; Guerra, Maria Das Graças Vale Barbosa ; Silva, Breno Melo ; De Melo, Fabrício Freire ; Norris, Douglas ; De Lacerda, Marcus Vinícius Guimarães ; Pimenta, Paulo Filemon Paolucci ; Secundino, Nágila Francinete Costa. / Coinfection with zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host. In: Journal of Infectious Diseases. 2018 ; Vol. 218, No. 4. pp. 563-571.
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abstract = "Background Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.",
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T1 - Coinfection with zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host

AU - Chaves, Barbara Aparecida

AU - Orfano, Alessandra Silva

AU - Nogueira, Paula Monalisa

AU - Rodrigues, Nilton Barnabe

AU - Campolina, Thais Bonifácio

AU - Nacif-Pimenta, Rafael

AU - Pires, Ana Clara Araújo Machado

AU - Júnior, Ademir Bentes Vieira

AU - Paz, Andréia Da Costa

AU - Vaz, Evelyn Beatriz Da Costa

AU - Guerra, Maria Das Graças Vale Barbosa

AU - Silva, Breno Melo

AU - De Melo, Fabrício Freire

AU - Norris, Douglas

AU - De Lacerda, Marcus Vinícius Guimarães

AU - Pimenta, Paulo Filemon Paolucci

AU - Secundino, Nágila Francinete Costa

PY - 2018/7/13

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N2 - Background Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.

AB - Background Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.

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