TY - JOUR
T1 - Coinfection with zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host
AU - Chaves, Barbara Aparecida
AU - Orfano, Alessandra Silva
AU - Nogueira, Paula Monalisa
AU - Rodrigues, Nilton Barnabe
AU - Campolina, Thais Bonifácio
AU - Nacif-Pimenta, Rafael
AU - Pires, Ana Clara Araújo Machado
AU - Júnior, Ademir Bentes Vieira
AU - Paz, Andréia Da Costa
AU - Vaz, Evelyn Beatriz Da Costa
AU - Guerra, Maria Das Graças Vale Barbosa
AU - Silva, Breno Melo
AU - De Melo, Fabrício Freire
AU - Norris, Douglas Eric
AU - De Lacerda, Marcus Vinícius Guimarães
AU - Pimenta, Paulo Filemon Paolucci
AU - Secundino, Nágila Francinete Costa
N1 - Funding Information:
Financial support. This work was supported by the Oswaldo Cruz Foundation, the Brazilian Council for Scientific and Technological Development, Science Without Borders, the Instituto Nacional de Ciência e Tecnologia (INCT)— Entomologia Molecular, the Minas Gerais State Research Support Foundation (FAPEMIG), the Federal University of Bahia Support Program for Young PhD Professors, the Amazonas State Research Support Foundation (FAPEAM), the Brazilian Comissão de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) (support to B. A. C., T. B. C., and R. N.-P.), and the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) (support to N. R. B., LV, A. S. O., N. F. C. S., M. V. G. d. L., and P. F. P. P.).
Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2018/7/13
Y1 - 2018/7/13
N2 - Background Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.
AB - Background Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.
KW - Aedes aegypti
KW - Coinfection
KW - Zika virus
KW - dengue virus
KW - preferential transmission
KW - vector bite
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U2 - 10.1093/infdis/jiy196
DO - 10.1093/infdis/jiy196
M3 - Article
C2 - 29659904
AN - SCOPUS:85050801319
SN - 0022-1899
VL - 218
SP - 563
EP - 571
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -