Coincident liposarcoma, carcinoid and gastrointestinal stromal tumor complicating type 1 neurofibromatosis: Case report and literature review

Aaron James, Le Chang, Scott Genshaft, Sarah M. Dry

Research output: Contribution to journalReview article


Neurofibromatosis type 1 (NF1) is associated with increased risk of multiple neoplasms. We present a case of a female patient with NF1 who presented with a rectal low-grade neuroendocrine (carcinoid) tumor. Computed tomography imaging found a well-differentiated liposarcoma and a well-circumscribed gastro-intestinal stromal tumor (GIST). Although GIST and carcinoid tumors are frequently found in NF1 patients, liposarcoma complicating NF1 is quite rare and this is the first reported case of well-differentiated liposarcoma in NF1. In summary, we report a case of coincident abdominal carcinoid tumor, GIST and well-differentiated liposarcoma, which illustrates the variability of neoplasms in NF1 patients.

Original languageEnglish (US)
Pages (from-to)S111-S116
JournalJournal of Orthopaedics
Publication statusPublished - Oct 1 2015
Externally publishedYes



  • Carcinoid
  • GIST
  • Malignant peripheral nerve sheath tumor
  • Type 1 neurofibromatosis
  • Well-differentiated liposarcoma

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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