Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis

F. Javier Nieto, Erwin Adam, Paul Sorlie, Homayoon Farzadegan, Joseph L. Melnick, George W. Comstock, Moyses Szklo

Research output: Contribution to journalArticle

Abstract

Background: Animal studies as well as clinical and cross sectional epidemiological studies in humans have suggested a possible role of cytomegalovirus (CMV) and other herpesvirus infections in the development of cardiovascular disease. Methods and Results: The present report is based on a case control study nested within a historical cohort. The case group comprised 150 individuals with elevated carotid intimal-medial thickness (IMT) measured by B-mode ultrasound at the first two examinations of the Atherosclerosis Risk in Communities (ARIC) Study (1987 through 1992). The control group comprised 150 age- and sex-matched individuals with low IMT. Antibody titers for CMV and herpesvirus 1 and 2 were determined in sera obtained in 1974 as part of a community-wide survey conducted in Washington Country, Maryland. Case subjects had higher mean CMV antibody titers in 1974 sera than control subjects, although the difference was not statistically significant when adjusted for other cardiovascular risk factors. There was evidence of a graded relation between the odds of intimal-medial thickening and the levels of CMV antibodies that remained significant alter adjustment for the main cardiovascular risk factors (P=.013). The adjusted odds ratio for a high CMV antibody titer (a positive/negative value ≤20) compared with a positive/negative value

Original languageEnglish (US)
Pages (from-to)922-927
Number of pages6
JournalCirculation
Volume94
Issue number5
StatePublished - 1996

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Tunica Intima
Cytomegalovirus Infections
Cytomegalovirus
Atherosclerosis
Cohort Studies
Antibodies
Herpesviridae Infections
Herpesviridae
Serum
Case-Control Studies
Epidemiologic Studies
Cardiovascular Diseases
Cross-Sectional Studies
Odds Ratio
Control Groups

Keywords

  • atherosclerosis
  • carotid arteries
  • follow-up studies
  • risk factors
  • viruses

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis. / Nieto, F. Javier; Adam, Erwin; Sorlie, Paul; Farzadegan, Homayoon; Melnick, Joseph L.; Comstock, George W.; Szklo, Moyses.

In: Circulation, Vol. 94, No. 5, 1996, p. 922-927.

Research output: Contribution to journalArticle

Nieto, F. Javier ; Adam, Erwin ; Sorlie, Paul ; Farzadegan, Homayoon ; Melnick, Joseph L. ; Comstock, George W. ; Szklo, Moyses. / Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis. In: Circulation. 1996 ; Vol. 94, No. 5. pp. 922-927.
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