Cohort profile: The International Collaboration of Incident HIV and Hepatitis C in Injecting Cohorts (InC3) Study

Jason Grebely, Meghan D. Morris, Thomas M. Rice, Julie Bruneau, Andrea L. Cox, Arthur Y. Kim, Barbara H. McGovern, Naglaa H. Shoukry, Georg Lauer, Lisa Maher, Andrew R. Lloyd, Margaret Hellard, Maria Prins, Gregory J. Dore, Kimberly Page

Research output: Contribution to journalArticle

Abstract

The International Collaboration of Incident HIV and Hepatitis C in Injecting Cohorts (InC3) Study is an international multi-cohort project of pooled biological and behavioural data from nine prospective cohorts of people who inject drugs (PWID). InC3 brings together researchers from Australia, Canada, USA and the Netherlands with expertise in epidemiology, biostatistics, clinical and behavioural sciences, virology and immunology to investigate research questions relevant to hepatitis C virus (HCV) and HIV outcomes. InC3 was established to: (i) create a merged multi-cohort study of pooled data from well-characterized cohorts of PWID with prospective data on HIV and HCV infections, with a particular focus on HCV; (ii) facilitate new studies not possible within individual cohorts; and (iii) bring together researchers across disciplines to answer a broad range of research questions. Study cohorts identify acute HCV cases through follow-up of high-risk HCV antibody-negative PWID or through clinical referral networks. To date, data from 1986 to 2010 have been received from all contributing cohorts, with 821 HCV-infected and 1216 HCV-uninfected participants (overall, n = 2037). Data collected include demographics, host genetics, HCV ribonucleic acid testing, alanine aminotransferase testing, HIV/hepatitis B virus testing, HCV therapy, loss to follow-up and mortality. Potential collaborators should contact the InC3 PI Dr Kimberley Page (kPage@psg.ucsf.edu) for further information. Published by Oxford University Press on behalf of the International Epidemiological Association

Original languageEnglish (US)
Article numberdys167
Pages (from-to)1649-1659
Number of pages11
JournalInternational journal of epidemiology
Volume42
Issue number6
DOIs
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Epidemiology

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    Grebely, J., Morris, M. D., Rice, T. M., Bruneau, J., Cox, A. L., Kim, A. Y., McGovern, B. H., Shoukry, N. H., Lauer, G., Maher, L., Lloyd, A. R., Hellard, M., Prins, M., Dore, G. J., & Page, K. (2013). Cohort profile: The International Collaboration of Incident HIV and Hepatitis C in Injecting Cohorts (InC3) Study. International journal of epidemiology, 42(6), 1649-1659. [dys167]. https://doi.org/10.1093/ije/dys167