Cohort profile

Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study

Yufang Bi, Jieli Lu, Weiqing Wang, Yiming Mu, Jiajun Zhao, Chao Liu, Lulu Chen, Lixin Shi, Qiang Li, Qin Wan, Shengli Wu, Tao Yang, Li Yan, Yan Liu, Guixia Wang, Zuojie Luo, Xulei Tang, Gang Chen, Yanan Huo, Zhengnan Gao & 19 others Qing Su, Zhen Ye, Youming Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Jie Zhang, Jichao Sun, Meng Dai, Min Xu, Yu Xu, Yuhong Chen, Shenghan Lai, Zachary T. Bloomgarden, Donghui Li, Guang Ning

Research output: Contribution to journalArticle

Abstract

Objective: To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods: Between 2011 and 2012, 259657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results: The mean ± standard deviation (SD) age of this cohort was 57±10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95% CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95% CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95% CI: 1.21-2.00), the endometrium (PR: 1.58, 95% CI: 1.16-2.15), and the thyroid (PR: 1.53, 95% CI: 1.03-2.27). Conclusion: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259657 adults from the general population across the China.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalJournal of Diabetes
Volume6
Issue number2
DOIs
StatePublished - Mar 2014

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Longitudinal Studies
Neoplasms
Glucose
Life Style
China
Independent Living
Prediabetic State
Endometrium
Population
Health Status
Stomach Neoplasms
Thyroid Gland
Urine
Breast Neoplasms
Psychology
DNA
Serum

Keywords

  • Cancer
  • Diabetes
  • REACTION study

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Cohort profile : Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study. / Bi, Yufang; Lu, Jieli; Wang, Weiqing; Mu, Yiming; Zhao, Jiajun; Liu, Chao; Chen, Lulu; Shi, Lixin; Li, Qiang; Wan, Qin; Wu, Shengli; Yang, Tao; Yan, Li; Liu, Yan; Wang, Guixia; Luo, Zuojie; Tang, Xulei; Chen, Gang; Huo, Yanan; Gao, Zhengnan; Su, Qing; Ye, Zhen; Wang, Youming; Qin, Guijun; Deng, Huacong; Yu, Xuefeng; Shen, Feixia; Chen, Li; Zhao, Liebin; Zhang, Jie; Sun, Jichao; Dai, Meng; Xu, Min; Xu, Yu; Chen, Yuhong; Lai, Shenghan; Bloomgarden, Zachary T.; Li, Donghui; Ning, Guang.

In: Journal of Diabetes, Vol. 6, No. 2, 03.2014, p. 147-157.

Research output: Contribution to journalArticle

Bi, Y, Lu, J, Wang, W, Mu, Y, Zhao, J, Liu, C, Chen, L, Shi, L, Li, Q, Wan, Q, Wu, S, Yang, T, Yan, L, Liu, Y, Wang, G, Luo, Z, Tang, X, Chen, G, Huo, Y, Gao, Z, Su, Q, Ye, Z, Wang, Y, Qin, G, Deng, H, Yu, X, Shen, F, Chen, L, Zhao, L, Zhang, J, Sun, J, Dai, M, Xu, M, Xu, Y, Chen, Y, Lai, S, Bloomgarden, ZT, Li, D & Ning, G 2014, 'Cohort profile: Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study', Journal of Diabetes, vol. 6, no. 2, pp. 147-157. https://doi.org/10.1111/1753-0407.12108
Bi, Yufang ; Lu, Jieli ; Wang, Weiqing ; Mu, Yiming ; Zhao, Jiajun ; Liu, Chao ; Chen, Lulu ; Shi, Lixin ; Li, Qiang ; Wan, Qin ; Wu, Shengli ; Yang, Tao ; Yan, Li ; Liu, Yan ; Wang, Guixia ; Luo, Zuojie ; Tang, Xulei ; Chen, Gang ; Huo, Yanan ; Gao, Zhengnan ; Su, Qing ; Ye, Zhen ; Wang, Youming ; Qin, Guijun ; Deng, Huacong ; Yu, Xuefeng ; Shen, Feixia ; Chen, Li ; Zhao, Liebin ; Zhang, Jie ; Sun, Jichao ; Dai, Meng ; Xu, Min ; Xu, Yu ; Chen, Yuhong ; Lai, Shenghan ; Bloomgarden, Zachary T. ; Li, Donghui ; Ning, Guang. / Cohort profile : Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study. In: Journal of Diabetes. 2014 ; Vol. 6, No. 2. pp. 147-157.
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abstract = "Objective: To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods: Between 2011 and 2012, 259657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results: The mean ± standard deviation (SD) age of this cohort was 57±10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32{\%} and 10.57{\%}, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95{\%} CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95{\%} CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95{\%} CI: 1.21-2.00), the endometrium (PR: 1.58, 95{\%} CI: 1.16-2.15), and the thyroid (PR: 1.53, 95{\%} CI: 1.03-2.27). Conclusion: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259657 adults from the general population across the China.",
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T1 - Cohort profile

T2 - Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study

AU - Bi, Yufang

AU - Lu, Jieli

AU - Wang, Weiqing

AU - Mu, Yiming

AU - Zhao, Jiajun

AU - Liu, Chao

AU - Chen, Lulu

AU - Shi, Lixin

AU - Li, Qiang

AU - Wan, Qin

AU - Wu, Shengli

AU - Yang, Tao

AU - Yan, Li

AU - Liu, Yan

AU - Wang, Guixia

AU - Luo, Zuojie

AU - Tang, Xulei

AU - Chen, Gang

AU - Huo, Yanan

AU - Gao, Zhengnan

AU - Su, Qing

AU - Ye, Zhen

AU - Wang, Youming

AU - Qin, Guijun

AU - Deng, Huacong

AU - Yu, Xuefeng

AU - Shen, Feixia

AU - Chen, Li

AU - Zhao, Liebin

AU - Zhang, Jie

AU - Sun, Jichao

AU - Dai, Meng

AU - Xu, Min

AU - Xu, Yu

AU - Chen, Yuhong

AU - Lai, Shenghan

AU - Bloomgarden, Zachary T.

AU - Li, Donghui

AU - Ning, Guang

PY - 2014/3

Y1 - 2014/3

N2 - Objective: To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods: Between 2011 and 2012, 259657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results: The mean ± standard deviation (SD) age of this cohort was 57±10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95% CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95% CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95% CI: 1.21-2.00), the endometrium (PR: 1.58, 95% CI: 1.16-2.15), and the thyroid (PR: 1.53, 95% CI: 1.03-2.27). Conclusion: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259657 adults from the general population across the China.

AB - Objective: To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods: Between 2011 and 2012, 259657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results: The mean ± standard deviation (SD) age of this cohort was 57±10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95% CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95% CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95% CI: 1.21-2.00), the endometrium (PR: 1.58, 95% CI: 1.16-2.15), and the thyroid (PR: 1.53, 95% CI: 1.03-2.27). Conclusion: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259657 adults from the general population across the China.

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