Cognitive reserve modulates ERPs associated with verbal working memory in healthy younger and older adults

Megan E. Speer, Anja Soldan

Research output: Contribution to journalArticle

Abstract

Although many epidemiological studies suggest the beneficial effects of higher cognitive reserve (CR) in reducing age-related cognitive decline and dementia risk, the neural basis of CR is poorly understood. To our knowledge, the present study represents the first electrophysiological investigation of the relationship between CR and neural reserve (i.e., neural efficiency and capacity). Specifically, we examined whether CR modulates event-related potentials associated with performance on a verbal recognition memory task with 3 set sizes (1, 4, or 7 letters) in healthy younger and older adults. Neural data showed that as task difficulty increased, the amplitude of the parietal P3b component during the probe phase decreased and its latency increased. Notably, the degree of these neural changes was negatively correlated with CR in both age groups, such that individuals with higher CR showed smaller changes in P3b amplitude and less slowing in P3b latency (i.e., smaller changes in the speed of neural processing) with increasing task difficulty, suggesting greater neural efficiency. These CR-related differences in neural efficiency may underlie reserve against neuropathology and age-related burden.

Original languageEnglish (US)
Pages (from-to)1424-1434
Number of pages11
JournalNeurobiology of Aging
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Cognitive Reserve
Short-Term Memory
Young Adult
Efficiency
Evoked Potentials
Dementia
Epidemiologic Studies
Age Groups

Keywords

  • Cognitive aging
  • Cognitive reserve
  • Event-related potentials (ERPs)
  • Neural efficiency
  • P3
  • Verbal working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Cognitive reserve modulates ERPs associated with verbal working memory in healthy younger and older adults. / Speer, Megan E.; Soldan, Anja.

In: Neurobiology of Aging, Vol. 36, No. 3, 01.03.2015, p. 1424-1434.

Research output: Contribution to journalArticle

@article{7b1ffaa56e4a46ef9aaca99f588d9e94,
title = "Cognitive reserve modulates ERPs associated with verbal working memory in healthy younger and older adults",
abstract = "Although many epidemiological studies suggest the beneficial effects of higher cognitive reserve (CR) in reducing age-related cognitive decline and dementia risk, the neural basis of CR is poorly understood. To our knowledge, the present study represents the first electrophysiological investigation of the relationship between CR and neural reserve (i.e., neural efficiency and capacity). Specifically, we examined whether CR modulates event-related potentials associated with performance on a verbal recognition memory task with 3 set sizes (1, 4, or 7 letters) in healthy younger and older adults. Neural data showed that as task difficulty increased, the amplitude of the parietal P3b component during the probe phase decreased and its latency increased. Notably, the degree of these neural changes was negatively correlated with CR in both age groups, such that individuals with higher CR showed smaller changes in P3b amplitude and less slowing in P3b latency (i.e., smaller changes in the speed of neural processing) with increasing task difficulty, suggesting greater neural efficiency. These CR-related differences in neural efficiency may underlie reserve against neuropathology and age-related burden.",
keywords = "Cognitive aging, Cognitive reserve, Event-related potentials (ERPs), Neural efficiency, P3, Verbal working memory",
author = "Speer, {Megan E.} and Anja Soldan",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.neurobiolaging.2014.12.025",
language = "English (US)",
volume = "36",
pages = "1424--1434",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Cognitive reserve modulates ERPs associated with verbal working memory in healthy younger and older adults

AU - Speer, Megan E.

AU - Soldan, Anja

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Although many epidemiological studies suggest the beneficial effects of higher cognitive reserve (CR) in reducing age-related cognitive decline and dementia risk, the neural basis of CR is poorly understood. To our knowledge, the present study represents the first electrophysiological investigation of the relationship between CR and neural reserve (i.e., neural efficiency and capacity). Specifically, we examined whether CR modulates event-related potentials associated with performance on a verbal recognition memory task with 3 set sizes (1, 4, or 7 letters) in healthy younger and older adults. Neural data showed that as task difficulty increased, the amplitude of the parietal P3b component during the probe phase decreased and its latency increased. Notably, the degree of these neural changes was negatively correlated with CR in both age groups, such that individuals with higher CR showed smaller changes in P3b amplitude and less slowing in P3b latency (i.e., smaller changes in the speed of neural processing) with increasing task difficulty, suggesting greater neural efficiency. These CR-related differences in neural efficiency may underlie reserve against neuropathology and age-related burden.

AB - Although many epidemiological studies suggest the beneficial effects of higher cognitive reserve (CR) in reducing age-related cognitive decline and dementia risk, the neural basis of CR is poorly understood. To our knowledge, the present study represents the first electrophysiological investigation of the relationship between CR and neural reserve (i.e., neural efficiency and capacity). Specifically, we examined whether CR modulates event-related potentials associated with performance on a verbal recognition memory task with 3 set sizes (1, 4, or 7 letters) in healthy younger and older adults. Neural data showed that as task difficulty increased, the amplitude of the parietal P3b component during the probe phase decreased and its latency increased. Notably, the degree of these neural changes was negatively correlated with CR in both age groups, such that individuals with higher CR showed smaller changes in P3b amplitude and less slowing in P3b latency (i.e., smaller changes in the speed of neural processing) with increasing task difficulty, suggesting greater neural efficiency. These CR-related differences in neural efficiency may underlie reserve against neuropathology and age-related burden.

KW - Cognitive aging

KW - Cognitive reserve

KW - Event-related potentials (ERPs)

KW - Neural efficiency

KW - P3

KW - Verbal working memory

UR - http://www.scopus.com/inward/record.url?scp=84923551062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923551062&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2014.12.025

DO - 10.1016/j.neurobiolaging.2014.12.025

M3 - Article

C2 - 25619663

AN - SCOPUS:84923551062

VL - 36

SP - 1424

EP - 1434

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 3

ER -