Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease

Daniel Weintraub; Tanya Simuni; Chelsea Caspell-Garcia; Christopher Coffey; Shirley Lasch; Andrew Siderowf; Dag Aarsland; Paolo Barone; David Burn; Lama M. Chahine; Jamie Eberling; Alberto J. Espay; Eric D. Foster; James B. Leverenz; Irene Litvan; Irene Richard; Matthew D. Troyer; Keith A. Hawkins; Kenneth Marek; Danna Jennings; Caroline Tanner; Karl Kieburtz; Werner Poewe; Brit Mollenhauer; Tatiana Foroud; Douglas Galasko; Todd Sherer; Sohini Chowdhury; Mark Frasier; Catherine Kopil; Vanessa Arnedo; Alice Rudolph; John Seibyl; Susan Mendick; Norbert Schuff; Chelsea Caspell; Liz Uribe; Eric Foster; Katherine Gloer; Jon Yankey; Arthur Toga; Dorit Berlin; Paola Casalin; Giulia Malferrari; John Trojanowski; Les Shaw; David Russell; Stewart Factor; Penelope Hogarth; David Standaert; Robert Hauser; Joseph Jankovic; Matthew Stern; Lama Chahine; Samuel Frank; Klaus Seppi; Holly Shill; Daniela Berg; Zoltan Mari; Nicola Pavese; Alberto Espay; Johnna Devoto; Dominic Rowe; Melanie Brandabur; Roy Alcalay; Eduardo Tolosa; Michele York; Laura Leary; Cheryl Riordan; Linda Rees; Alicia Portillo; Art Lenahan; Karen Williams; Stephanie Guthrie; Ashlee Rawlins; Sherry Harlan; Christine Hunter; Baochan Tran; Cathi Ann Thomas; Raymond James; Fabienne Sprenger; Diana Willeke; Sanja Obradov; Jennifer Mule; Katharina Gauss; Deborah Fontaine; Bina Shah; Madelaine Ranola; John R. Sims

doi:10.1002/mds.26170

Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease

Daniel Weintraub, Tanya Simuni, Chelsea Caspell-Garcia, Christopher Coffey, Shirley Lasch, Andrew Siderowf, Dag Aarsland, Paolo Barone, David Burn, Lama M. Chahine, Jamie Eberling, Alberto J. Espay, Eric D. Foster, James B. Leverenz, Irene Litvan, Irene Richard, Matthew D. Troyer, Keith A. Hawkins, Kenneth Marek, Danna JenningsCaroline Tanner, Karl Kieburtz, Werner Poewe, Brit Mollenhauer, Tatiana Foroud, Douglas Galasko, Todd Sherer, Sohini Chowdhury, Mark Frasier, Catherine Kopil, Vanessa Arnedo, Alice Rudolph, John Seibyl, Susan Mendick, Norbert Schuff, Chelsea Caspell, Liz Uribe, Eric Foster, Katherine Gloer, Jon Yankey, Arthur Toga, Dorit Berlin, Paola Casalin, Giulia Malferrari, John Trojanowski, Les Shaw, David Russell, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Matthew Stern, Lama Chahine, Samuel Frank, Klaus Seppi, Holly Shill, Daniela Berg, Zoltan Mari, Nicola Pavese, Alberto Espay, Johnna Devoto, Dominic Rowe, Melanie Brandabur, Roy Alcalay, Eduardo Tolosa, Michele York, Laura Leary, Cheryl Riordan, Linda Rees, Alicia Portillo, Art Lenahan, Karen Williams, Stephanie Guthrie, Ashlee Rawlins, Sherry Harlan, Christine Hunter, Baochan Tran, Cathi Ann Thomas, Raymond James, Fabienne Sprenger, Diana Willeke, Sanja Obradov, Jennifer Mule, Katharina Gauss, Deborah Fontaine, Bina Shah, Madelaine Ranola, John R. Sims

School of Medicine

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

This study was undertaken to determine the prevalence and correlates of cognitive impairment (CI) and neuropsychiatric symptoms (NPS) in early, untreated patients with Parkinson's disease (PD). Background: Both CI and NPS are common in PD and impact disease course and quality of life. However, limited knowledge is available about cognitive abilities and NPS. Methods: Parkinson's Progression Markers Initiative (PPMI) is a multi-site study of early, untreated PD patients and healthy controls (HCs), the latter with normal cognition. At baseline, participants were assessed with a neuropsychological battery and for symptoms of depression, anxiety, impulse control disorders (ICDs), psychosis, and apathy. Results: Baseline data of 423 PD patients and 196 HCs yielded no between-group differences in demographic characteristics. Twenty-two percent of PD patients met the PD-recommended screening cutoff for CI on the Montral Cognitive Assessment (MoCA), but only 9% met detailed neuropsychological testing criteria for mild cognitive impairment (MCI)-level impairment. The PD patients were more depressed than HCs (P

Original language	English (US)
Pages (from-to)	919-927
Number of pages	9
Journal	Movement disorders : official journal of the Movement Disorder Society
Volume	30
Issue number	7
DOIs	https://doi.org/10.1002/mds.26170
State	Published - Jun 1 2015

Keywords

Anxiety
Apathy
Cognition
Depression
Impulse control disorder
Parkinson's disease
Psychosis

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1002/mds.26170

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Weintraub, D., Simuni, T., Caspell-Garcia, C., Coffey, C., Lasch, S., Siderowf, A., Aarsland, D., Barone, P., Burn, D., Chahine, L. M., Eberling, J., Espay, A. J., Foster, E. D., Leverenz, J. B., Litvan, I., Richard, I., Troyer, M. D., Hawkins, K. A., Marek, K., ... Sims, J. R. (2015). Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 30(7), 919-927. https://doi.org/10.1002/mds.26170

Weintraub, D, Simuni, T, Caspell-Garcia, C, Coffey, C, Lasch, S, Siderowf, A, Aarsland, D, Barone, P, Burn, D, Chahine, LM, Eberling, J, Espay, AJ, Foster, ED, Leverenz, JB, Litvan, I, Richard, I, Troyer, MD, Hawkins, KA, Marek, K, Jennings, D, Tanner, C, Kieburtz, K, Poewe, W, Mollenhauer, B, Foroud, T, Galasko, D, Sherer, T, Chowdhury, S, Frasier, M, Kopil, C, Arnedo, V, Rudolph, A, Seibyl, J, Mendick, S, Schuff, N, Caspell, C, Uribe, L, Foster, E, Gloer, K, Yankey, J, Toga, A, Berlin, D, Casalin, P, Malferrari, G, Trojanowski, J, Shaw, L, Russell, D, Factor, S, Hogarth, P, Standaert, D, Hauser, R, Jankovic, J, Stern, M, Chahine, L, Frank, S, Seppi, K, Shill, H, Berg, D, Mari, Z, Pavese, N, Espay, A, Devoto, J, Rowe, D, Brandabur, M, Alcalay, R, Tolosa, E, York, M, Leary, L, Riordan, C, Rees, L, Portillo, A, Lenahan, A, Williams, K, Guthrie, S, Rawlins, A, Harlan, S, Hunter, C, Tran, B, Thomas, CA, James, R, Sprenger, F, Willeke, D, Obradov, S, Mule, J, Gauss, K, Fontaine, D, Shah, B, Ranola, M & Sims, JR 2015, 'Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease', Movement disorders : official journal of the Movement Disorder Society, vol. 30, no. 7, pp. 919-927. https://doi.org/10.1002/mds.26170

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abstract = "This study was undertaken to determine the prevalence and correlates of cognitive impairment (CI) and neuropsychiatric symptoms (NPS) in early, untreated patients with Parkinson's disease (PD). Background: Both CI and NPS are common in PD and impact disease course and quality of life. However, limited knowledge is available about cognitive abilities and NPS. Methods: Parkinson's Progression Markers Initiative (PPMI) is a multi-site study of early, untreated PD patients and healthy controls (HCs), the latter with normal cognition. At baseline, participants were assessed with a neuropsychological battery and for symptoms of depression, anxiety, impulse control disorders (ICDs), psychosis, and apathy. Results: Baseline data of 423 PD patients and 196 HCs yielded no between-group differences in demographic characteristics. Twenty-two percent of PD patients met the PD-recommended screening cutoff for CI on the Montral Cognitive Assessment (MoCA), but only 9% met detailed neuropsychological testing criteria for mild cognitive impairment (MCI)-level impairment. The PD patients were more depressed than HCs (P",

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AU - Weintraub, Daniel

AU - Simuni, Tanya

AU - Caspell-Garcia, Chelsea

AU - Coffey, Christopher

AU - Lasch, Shirley

AU - Siderowf, Andrew

AU - Aarsland, Dag

AU - Barone, Paolo

AU - Burn, David

AU - Chahine, Lama M.

AU - Eberling, Jamie

AU - Espay, Alberto J.

AU - Foster, Eric D.

AU - Leverenz, James B.

AU - Litvan, Irene

AU - Richard, Irene

AU - Troyer, Matthew D.

AU - Hawkins, Keith A.

AU - Marek, Kenneth

AU - Jennings, Danna

AU - Tanner, Caroline

AU - Kieburtz, Karl

AU - Poewe, Werner

AU - Mollenhauer, Brit

AU - Foroud, Tatiana

AU - Galasko, Douglas

AU - Sherer, Todd

AU - Chowdhury, Sohini

AU - Frasier, Mark

AU - Kopil, Catherine

AU - Arnedo, Vanessa

AU - Rudolph, Alice

AU - Seibyl, John

AU - Mendick, Susan

AU - Schuff, Norbert

AU - Caspell, Chelsea

AU - Uribe, Liz

AU - Foster, Eric

AU - Gloer, Katherine

AU - Yankey, Jon

AU - Toga, Arthur

AU - Berlin, Dorit

AU - Casalin, Paola

AU - Malferrari, Giulia

AU - Trojanowski, John

AU - Shaw, Les

AU - Russell, David

AU - Factor, Stewart

AU - Hogarth, Penelope

AU - Standaert, David

AU - Hauser, Robert

AU - Jankovic, Joseph

AU - Stern, Matthew

AU - Chahine, Lama

AU - Frank, Samuel

AU - Seppi, Klaus

AU - Shill, Holly

AU - Berg, Daniela

AU - Mari, Zoltan

AU - Pavese, Nicola

AU - Espay, Alberto

AU - Devoto, Johnna

AU - Rowe, Dominic

AU - Brandabur, Melanie

AU - Alcalay, Roy

AU - Tolosa, Eduardo

AU - York, Michele

AU - Leary, Laura

AU - Riordan, Cheryl

AU - Rees, Linda

AU - Portillo, Alicia

AU - Lenahan, Art

AU - Williams, Karen

AU - Guthrie, Stephanie

AU - Rawlins, Ashlee

AU - Harlan, Sherry

AU - Hunter, Christine

AU - Tran, Baochan

AU - Thomas, Cathi Ann

AU - James, Raymond

AU - Sprenger, Fabienne

AU - Willeke, Diana

AU - Obradov, Sanja

AU - Mule, Jennifer

AU - Gauss, Katharina

AU - Fontaine, Deborah

AU - Shah, Bina

AU - Ranola, Madelaine

AU - Sims, John R.

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Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease

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