Cognitive performance and autonomic reactivity in abstinent drug abusers and nonusers

Diana Fishbein; Chris Hyde; Diana Eldreth; Edythe B. London; John Matochik; Monique Ernst; Nancy Isenberg; Stacey Steckley; Barry Schech; Alane Kimes

doi:10.1037/1064-1297.13.1.25

Cognitive performance and autonomic reactivity in abstinent drug abusers and nonusers

Diana Fishbein, Chris Hyde, Diana Eldreth, Edythe B. London, John Matochik, Monique Ernst, Nancy Isenberg, Stacey Steckley, Barry Schech, Alane Kimes

School of Medicine

Research output: Contribution to journal › Article

Abstract

In this study the authors compared the performance of abstinent drug abusers (n = 21) and nonuser control participants (n = 20) in neurocognitive and emotional functions by use of the Rogers Decision Making Task, Gambling Task, Emotional Stroop, impulsivity continuous performance task (CPT), and vigilance CPT. Skin conductance (SC) and heart rate (HR) monitoring was synchronized with task performance. Groups showed similar performance for vigilance, impulsivity, and emotional interference; however, drug abusers showed stronger SC responses. Drug abusers performed more poorly on the Gambling and Rogers Decision Making Tasks. When making risky decisions, drug abusers showed significantly less increase in SC activity than controls and exhibited lower HRs throughout performance on all tasks. In conclusion, complex tasks involving decision making, sensitivity to consequences, and emotional regulation discriminated between drug abusers and controls.

Original language	English (US)
Pages (from-to)	25-40
Number of pages	16
Journal	Experimental and clinical psychopharmacology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1037/1064-1297.13.1.25
State	Published - Feb 1 2005

Keywords

Decision-making
Drug abuse
Executive cognition
Prefrontal cortex
Skin conductance

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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Fishbein, D., Hyde, C., Eldreth, D., London, E. B., Matochik, J., Ernst, M., Isenberg, N., Steckley, S., Schech, B., & Kimes, A. (2005). Cognitive performance and autonomic reactivity in abstinent drug abusers and nonusers. Experimental and clinical psychopharmacology, 13(1), 25-40. https://doi.org/10.1037/1064-1297.13.1.25

Cognitive performance and autonomic reactivity in abstinent drug abusers and nonusers. / Fishbein, Diana; Hyde, Chris; Eldreth, Diana; London, Edythe B.; Matochik, John; Ernst, Monique; Isenberg, Nancy; Steckley, Stacey; Schech, Barry; Kimes, Alane.

In: Experimental and clinical psychopharmacology, Vol. 13, No. 1, 01.02.2005, p. 25-40.

Research output: Contribution to journal › Article

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