Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials

Akio Ikeda, Shogo Yazawa, Takeharu Kunieda, Shinji Ohara, Kiyohito Terada, Nobuhiro Mikuni, Takashi Nagamine, Waro Taki, Jun Kimura, Hiroshi Shibasaki

Research output: Contribution to journalArticle

Abstract

To clarify the functional role of human pre-supplementary motor area (pre-SMA) in 'cognitive' motor control as compared with other non-primary motor cortices (SMA-proper and lateral premotor areas) and prefrontal area, we recorded epicortical field potentials by using subdural electrodes in five epileptic patients during presurgical evaluation, whose pre-SMA, SMA-proper, prefrontal and lateral premotor areas were defined by electric cortical stimulation and recent anatomical orientations according to the bicommissural plane and callosal grid system. An S1-Go/NoGo choice and delayed reaction task (S1-choice paradigm) and a warned choice Go/NoGo reaction task (S2-choice paradigm) with inter-stimulus intervals of 2 s were employed. The results showed (i) transient potentials with onset and peak latencies of about 200 and 600 ms, respectively, after S1 in the S1-choice paradigm mainly at pre-SMA and to a lesser degree at the prefrontal and lateral premotor areas, but not in the S2-choice paradigm. At SMA-proper, a similar but much smaller potential was seen after S1 in both S1- and S2-choice paradigms and (ii) slow sustained potentials between S1 and S2 in both S1- and S2-choice paradigms in all of the non-primary motor areas investigated (pre-SMA, SMA-proper and lateral premotor areas) and prefrontal area. It is concluded that pre-SMA plays a more important role in cognitive motor control which involves sensory discrimination and decision making or motor selection for the action after stimuli, whereas SMA-proper is one of the main generators of Bereitschaftspotential preceding self-paced, voluntary movements. In the more general anticipation of and attention to the forthcoming stimuli, non-primary motor cortices including pre-SMA, SMA-proper and lateral premotor area, and the prefrontal area are commonly involved.

Original languageEnglish (US)
Pages (from-to)915-931
Number of pages17
JournalBrain
Volume122
Issue number5
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Choice paradigm
  • Pre-SMA
  • Selection
  • Subdural recording
  • Voluntary movements

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Ikeda, A., Yazawa, S., Kunieda, T., Ohara, S., Terada, K., Mikuni, N., Nagamine, T., Taki, W., Kimura, J., & Shibasaki, H. (1999). Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials. Brain, 122(5), 915-931. https://doi.org/10.1093/brain/122.5.915