Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: Randomized controlled trial of olanzapine vs amisulpride

Michael Wagner, Boris B. Quednow, Jens Westheide, Thomas E. Schlaepfer, Wolfgang Maier, Kai Uwe Kühn

Research output: Contribution to journalArticle

Abstract

Combined serotonin-2A (5-HT2A) and dopamine-2 (D2) receptor blockade has been proposed as a candidate mechanism by which second-generation antipsychotics (SGAs) improve both cognition and negative symptoms in schizophrenic patients, in contrast to antipsychotics of the first generation. The SGA amisulpride, however, only binds to D2/D 3 receptors, which makes it an interesting tool to test this assumption. In a randomized controlled trial, 52 schizophrenic patients were allocated to treatment with either olanzapine (10-20 mg/day) or amisulpride (400-800 mg/day). A comprehensive neuropsychological test battery and clinical ratings were used to assess participants at inclusion and after 4 and 8 weeks. Cognitive improvements of moderate size were observed, with effect sizes similar to those obtained in previous studies on the cognitive effects of SGAs. Importantly, amisulpride was not inferior to olanzapine for any cognitive domain. Combined 5-HT2A/D2 receptor blockade is probably not necessary for cognitive improvement by SGAs.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalNeuropsychopharmacology
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Keywords

  • 5-HT receptor
  • Amisulpride
  • Antipsychotics
  • Cognition
  • Olanzapine
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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