Cognitive impairment in mice over-expressing γ-aminobutyric acid transporter 1 (GAT1)

Jia Hua Hu, Ying Hua Ma, Jie Jiang, Na Yang, Shu Hui Duan, Zhi Hua Jiang, Zhen Tong Mei, Jian Fei, Li He Guo

Research output: Contribution to journalArticlepeer-review

Abstract

There is increasing evidence that GABAergic system plays an important role in the neural control of learning and memory processes. GAT1 over-expressing mice (NA) were generated, in which GAT1 is under the control of a neuron-specific enolase (NSE) promoter, to investigate effects of GABA transporter on cognitive function. Our results revealed that NA mice displayed cognitive deterioration in associative learning ability and new object recognition retention, compared with the wild-type littermates (WT2). However, the impaired cognitive function of transgenic mice could be rescued after chronic administration of GAT1 selective inhibitor for 6 days. In addition, there was no change of the expression of NMDA receptors in NA mice. Taken together, we show a potentially important role for GAT1 in the neural control of cognitive processes, and indicate great potential for GAT1 as a clinical target of cognitive disorders.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalNeuroreport
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • Cognitive
  • GABA transporter
  • GABAergic system
  • Hippocampus
  • Over-expressing
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)

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