Cognitive functioning in recent onset psychosis

Faith Dickerson, Cassie Stallings, Crystal Vaughan, Andrea Origoni, Sunil Khushalani, Dwight Dickinson, Deborah Medoff

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of the study was to compare the cognitive functioning of persons with a recent onset of psychosis with schizophrenia-spectrum disorders and bipolar disorder and nonpsychiatric controls. A total of 56 persons with a schizophrenia-spectrum disorder and 60 with bipolar disorder, all with a recent onset psychosis, and 312 nonpsychiatric controls were evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Wisconsin Card Sorting Test (WCST). Comparison of the three groups through analysis of covariance indicated a significant difference among the groups for all of the cognitive variables. Pairwise contrasts of the two recent onset groups showed a significant difference favoring the bipolar disorder group on RBANS Language (p = 0.020) and Total (p = 0.050) and a marginally significant difference on RBANS Immediate Memory (p = 0.053) but not on the other RBANS variables or on the WCST. Cognitive performance is broadly impaired in recent onset psychosis, with a cognitive advantage to bipolar disorder patients compared with schizophrenia-spectrum patients.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalJournal of Nervous and Mental Disease
Volume199
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • bipolar disorder
  • Cognitive functioning
  • recent onset psychosis
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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