Cognitive function in families with exceptional survival

Sandra Barral, Stephanie Cosentino, Rosann Costa, Amy Matteini, Kaare Christensen, Stacy L. Andersen, Nancy W. Glynn, Anne B. Newman, Richard Mayeux

Research output: Contribution to journalArticle

Abstract

The authors investigated whether cognitive function may be used as an endophenotype for longevity by assessing the cognitive performance of a family-based cohort consisting of 1380 individuals from 283 families recruited for exceptional survival in field centers in Boston, New York, Pittsburgh, and Denmark. Cognitive performance was assessed in the combined offspring of the Long Life Family Study (LLFS) probands and their LLFS siblings as compared with their spouses' cognitive performance. Our results indicate that the combined offspring of the LLFS probands and their siblings achieve significantly higher scores on both digit forward and backward tasks (p = 5 10 -5 and p = 8 10 -4 respectively) as well as on a verbal fluency task (p = 0.008) when compared with their spouse controls. No differences between groups were found for the other cognitive tests assessed. We conclude that LLFS family members in the offspring generation demonstrate significantly better performance on multiple tasks requiring attention, working memory, and semantic processing when compared with individuals without a family history of exceptional survival, suggesting that cognitive performance may serve as an important endophenotype for longevity.

Original languageEnglish (US)
JournalNeurobiology of Aging
Volume33
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Cognition
Survival
Endophenotypes
Spouses
Siblings
Denmark
Short-Term Memory
Semantics

Keywords

  • Cognitive performance
  • Endophenotype
  • Exceptional survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Barral, S., Cosentino, S., Costa, R., Matteini, A., Christensen, K., Andersen, S. L., ... Mayeux, R. (2012). Cognitive function in families with exceptional survival. Neurobiology of Aging, 33(3). https://doi.org/10.1016/j.neurobiolaging.2011.02.004

Cognitive function in families with exceptional survival. / Barral, Sandra; Cosentino, Stephanie; Costa, Rosann; Matteini, Amy; Christensen, Kaare; Andersen, Stacy L.; Glynn, Nancy W.; Newman, Anne B.; Mayeux, Richard.

In: Neurobiology of Aging, Vol. 33, No. 3, 03.2012.

Research output: Contribution to journalArticle

Barral, S, Cosentino, S, Costa, R, Matteini, A, Christensen, K, Andersen, SL, Glynn, NW, Newman, AB & Mayeux, R 2012, 'Cognitive function in families with exceptional survival', Neurobiology of Aging, vol. 33, no. 3. https://doi.org/10.1016/j.neurobiolaging.2011.02.004
Barral S, Cosentino S, Costa R, Matteini A, Christensen K, Andersen SL et al. Cognitive function in families with exceptional survival. Neurobiology of Aging. 2012 Mar;33(3). https://doi.org/10.1016/j.neurobiolaging.2011.02.004
Barral, Sandra ; Cosentino, Stephanie ; Costa, Rosann ; Matteini, Amy ; Christensen, Kaare ; Andersen, Stacy L. ; Glynn, Nancy W. ; Newman, Anne B. ; Mayeux, Richard. / Cognitive function in families with exceptional survival. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 3.
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