Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression

Berta Sunyer, Wei Fei Diao, Ung Kang Sung, Gunyong An, Sanjay Boddul, Gert Lubec

Research output: Contribution to journalArticle

Abstract

Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.

Original languageEnglish (US)
Pages (from-to)5237-5253
Number of pages17
JournalJournal of proteome research
Volume7
Issue number12
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Keywords

  • Behavior
  • Cognitive
  • Drug
  • GABA (B) receptors
  • Hippocampus
  • Spatial memory

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression'. Together they form a unique fingerprint.

  • Cite this