Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression

Berta Sunyer; Wei Fei Diao; Ung Kang Sung; Gunyong An; Sanjay Boddul; Gert Lubec

doi:10.1021/pr800594b

Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression

Berta Sunyer, Wei Fei Diao, Ung Kang Sung, Gunyong An, Sanjay Boddul, Gert Lubec

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.

Original language	English (US)
Pages (from-to)	5237-5253
Number of pages	17
Journal	Journal of proteome research
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/pr800594b
State	Published - Dec 1 2008
Externally published	Yes

Keywords

Behavior
Cognitive
Drug
GABA (B) receptors
Hippocampus
Spatial memory

ASJC Scopus subject areas

Biochemistry
General Chemistry

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10.1021/pr800594b

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title = "Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression",

abstract = "Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.",

keywords = "Behavior, Cognitive, Drug, GABA (B) receptors, Hippocampus, Spatial memory",

author = "Berta Sunyer and Diao, {Wei Fei} and Sung, {Ung Kang} and Gunyong An and Sanjay Boddul and Gert Lubec",

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T1 - Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression

AU - Sunyer, Berta

AU - Diao, Wei Fei

AU - Sung, Ung Kang

AU - An, Gunyong

AU - Boddul, Sanjay

AU - Lubec, Gert

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.

AB - Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.

KW - Behavior

KW - Cognitive

KW - Drug

KW - GABA (B) receptors

KW - Hippocampus

KW - Spatial memory

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Cognitive enhancement by SGS742 in OF1 mice is linked to specific hippocampal protein expression

Abstract

Keywords

ASJC Scopus subject areas

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