Cognitive dysfunction in ICU patients: Risk factors, predictors, and rehabilitation interventions

M. Elizabeth Wilcox, Nathan E. Brummel, Kristin Archer, E. Wesley Ely, James C. Jackson, Ramona O. Hopkins

Research output: Contribution to journalArticle

Abstract

In contrast to other clinical outcomes, long-term cognitive function in critical care survivors has not been deeply studied. In this narrative review, we summarize the existing literature on the prevalence, mechanisms, risk factors, and prediction of cognitive impairment after surviving critical illness. Depending on the exact clinical subgroup, up to 100% of critical care survivors may suffer some degree of long-term cognitive impairment at hospital discharge; in approximately 50%, decrements in cognitive function will persist years later. Although the mechanisms of acquiring this impairment are poorly understood, several risk factors have been identified. Unfortunately, no easy means of predicting long-term cognitive impairment exists. Despite this barrier, research is ongoing to test possible treatments for cognitive impairment. In particular, the potential role of exercise on cognitive recovery is an exciting area of exploration. Opportunities exist to incorporate physical and cognitive rehabilitation strategies across a spectrum of environments (in the ICU, on the hospital ward, and at home, posthospital discharge).

Original languageEnglish (US)
JournalCritical Care Medicine
Volume41
Issue number9 SUPPL.1
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Rehabilitation
Critical Care
Cognition
Survivors
Critical Illness
Exercise
Cognitive Dysfunction
Research
Therapeutics

Keywords

  • adult respiratory distress syndrome
  • cognitive impairment
  • critical illness
  • disability
  • ICU
  • intervention
  • rehabilitation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Elizabeth Wilcox, M., Brummel, N. E., Archer, K., Wesley Ely, E., Jackson, J. C., & Hopkins, R. O. (2013). Cognitive dysfunction in ICU patients: Risk factors, predictors, and rehabilitation interventions. Critical Care Medicine, 41(9 SUPPL.1). https://doi.org/10.1097/CCM.0b013e3182a16946

Cognitive dysfunction in ICU patients : Risk factors, predictors, and rehabilitation interventions. / Elizabeth Wilcox, M.; Brummel, Nathan E.; Archer, Kristin; Wesley Ely, E.; Jackson, James C.; Hopkins, Ramona O.

In: Critical Care Medicine, Vol. 41, No. 9 SUPPL.1, 2013.

Research output: Contribution to journalArticle

Elizabeth Wilcox, M, Brummel, NE, Archer, K, Wesley Ely, E, Jackson, JC & Hopkins, RO 2013, 'Cognitive dysfunction in ICU patients: Risk factors, predictors, and rehabilitation interventions', Critical Care Medicine, vol. 41, no. 9 SUPPL.1. https://doi.org/10.1097/CCM.0b013e3182a16946
Elizabeth Wilcox, M. ; Brummel, Nathan E. ; Archer, Kristin ; Wesley Ely, E. ; Jackson, James C. ; Hopkins, Ramona O. / Cognitive dysfunction in ICU patients : Risk factors, predictors, and rehabilitation interventions. In: Critical Care Medicine. 2013 ; Vol. 41, No. 9 SUPPL.1.
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