Cognitive development in children with new onset epilepsy

Paul J. Rathouz, Qianqian Zhao, Jana E. Jones, Daren C. Jackson, David A. Hsu, Carl Stafstrom, Michael Seidenberg, Bruce P. Hermann

Research output: Contribution to journalArticle

Abstract

Aim: To characterize the prospective trajectory of cognitive development in children with new or recent onset epilepsy from baseline to 5 to 6 years after diagnosis. Method: Sixty-nine children (40 males, 29 females; age 8-18y), with new or recent onset epilepsies underwent neuropsychological assessment shortly after diagnosis (Wave 1), 2 years (Wave 2), and 5 to 6 years after diagnosis (Wave 3). Intelligence, academic achievement, language, executive function, and psychomotor speed were evaluated. Sixty-two children (28 males, 34 females; age 8-18) with typical development served as a comparison group at each time point. The cognitive data were examined by syndrome (localization-related epilepsy [LRE]; idiopathic generalized epilepsy [IGE]; comparison group). Mixed effect regression models compared trajectories among groups with respect to time since diagnosis. Results: Cognitive abnormalities exhibited by children with epilepsy in arithmetic computation, response inhibition, attention, fine motor dexterity, and psychomotor speed (all p values

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalDevelopmental Medicine and Child Neurology
Volume56
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

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Child Development
Epilepsy
Partial Epilepsy
Executive Function
Intelligence
Language

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience

Cite this

Rathouz, P. J., Zhao, Q., Jones, J. E., Jackson, D. C., Hsu, D. A., Stafstrom, C., ... Hermann, B. P. (2014). Cognitive development in children with new onset epilepsy. Developmental Medicine and Child Neurology, 56(7), 635-641. https://doi.org/10.1111/dmcn.12432

Cognitive development in children with new onset epilepsy. / Rathouz, Paul J.; Zhao, Qianqian; Jones, Jana E.; Jackson, Daren C.; Hsu, David A.; Stafstrom, Carl; Seidenberg, Michael; Hermann, Bruce P.

In: Developmental Medicine and Child Neurology, Vol. 56, No. 7, 2014, p. 635-641.

Research output: Contribution to journalArticle

Rathouz, PJ, Zhao, Q, Jones, JE, Jackson, DC, Hsu, DA, Stafstrom, C, Seidenberg, M & Hermann, BP 2014, 'Cognitive development in children with new onset epilepsy', Developmental Medicine and Child Neurology, vol. 56, no. 7, pp. 635-641. https://doi.org/10.1111/dmcn.12432
Rathouz, Paul J. ; Zhao, Qianqian ; Jones, Jana E. ; Jackson, Daren C. ; Hsu, David A. ; Stafstrom, Carl ; Seidenberg, Michael ; Hermann, Bruce P. / Cognitive development in children with new onset epilepsy. In: Developmental Medicine and Child Neurology. 2014 ; Vol. 56, No. 7. pp. 635-641.
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