Cognitive deficits in patients with chronic fatigue syndrome

Barbara Marcel, Anthony L. Komaroff, Laura R. Fagioli, R. James Kornish, Marilyn S. Albert

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Twenty-nine subjects with chronic fatigue syndrome (CFS) and 25 healthy control subjects were administered a lengthy neuropsychological battery that included standard neuropsychological tests and a computerized set of tasks that spanned the same areas of ability. The primary significant differences between patients and controls were found on tests of learning and memory. These differences remained when the degree of psychiatric symptomatology in the subjects was covaried. Patients on and of psychoactive medications did not differ in their performance an these tasks. These results suggest that at least a subset of CFS patients may experience significant impairments in learning and memory.

Original languageEnglish (US)
Pages (from-to)535-541
Number of pages7
JournalBiological psychiatry
Issue number6
StatePublished - Sep 15 1996
Externally publishedYes


  • CFS
  • Cognition
  • ME
  • Memory
  • Psychiatric symptoms

ASJC Scopus subject areas

  • Biological Psychiatry


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