Cognitive deficiency following childhood cranial radiation therapy for brain tumors

John M. Sheldon, Moody D. Wharam

Research output: Contribution to journalArticlepeer-review


Cognitive dysfunction is a common and disabling sequela of the multimodal treatment of brain tumors in children. Although its etiology is multifactorial and complex, cranial radiotherapy is a major factor. Younger children are most susceptible to cognitive impairment; treatment effects become magnified with a more immature central nervous system. Treatment strategies aimed at reducing the incidence and severity of cognitive deficiency in children <3 include radiotherapy dose reduction, preirradiation chemotherapy, and primary chemotherapy. A new strategy being investigated is hyper-fractionated radiotherapy. With all treatment approaches, a balance must be struck between disease control and reduction of treatment morbidity—particularly cognitive decline.

Original languageEnglish (US)
Pages (from-to)99-115
Number of pages17
JournalNeurosurgery Quarterly
Issue number2
StatePublished - Jun 1992


  • Brain tumor
  • Childhood
  • Cognitive deficiency
  • Cranial radiation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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