Cognitive decline in adulthood: An 11.5-year follow-up of the Baltimore Epidemiologic Catchment Area study

Constantine G Lyketsos, Li Shiun Chen, James C. Anthony

Research output: Contribution to journalArticle

Abstract

Objective: The epidemiology of cognitive decline over 11.5 years was investigated in a large community-residing population, with a special emphasis on the relationship between education and cognitive decline. Method: The study was an 11.5-year follow-up of a probability sample of the adult household residents of east Baltimore. From the Baltimore cohort of the Epidemiologic Catchment Area study, 1,488 participants completed the Mini- Mental State during three study waves in 1981, 1982, and 1993-1996. For each study participant, the difference in scores on the Mini-Mental State between waves 2 and 3 was calculated. Results: Over a median interval of 11.5 years, the study participants' scores on the Mini-Mental State declined a mean of 1.41 points, and the scores of 68% of the participants declined by at least 1 Mini-Mental State point. With and without adjustment for age, greater declines were associated with having 8 years or less of formal education and with being African American. Conclusions: Over a long time period, cognitive decline occurred in all age groups. Having more than 8 years of formal education was associated with less decline. However, beyond 9 years, additional education was not associated with a further reduction in cognitive decline. This suggests that a minimal amount of education during early critical periods might confer protection against cognitive decline later in life.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalAmerican Journal of Psychiatry
Volume156
Issue number1
StatePublished - Jan 1999

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ASJC Scopus subject areas

  • Psychiatry and Mental health

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