TY - JOUR
T1 - Cognitive and motor correlates of everyday functioning in early huntington’s disease
AU - Rothlind, Johannes C.
AU - Bylsma, Frederick W.
AU - Peyser, Carol
AU - Folstein, Susan E.
AU - Brandt, Jason
PY - 1993/3
Y1 - 1993/3
N2 - The present study documents the prevalence of deficits in the ability to carry out a variety of activities of daily living in early Huntington’s disease (HD), along with the associated neuropsychological and motor deficits. Eighty patients with HD were assessed with the Huntington’s Disease-Activities of Daily Living Questionnaire (HD-ADL). Sixty-seven patients also completed a comprehensive assessment of cognitive and voluntary motor functioning and chorea. The latter measures were correlated with HD-ADL total score and with most HD-ADL items, but not with those items dealing with marital and family relationship adjustment. Findings suggest that psychomotor speed and the ability to regulate attention may be particularly important determinants of everyday functioning in mild HD. Consistent with previously reported observations, this appears to be true even after accounting for individual differences in the severity of chorea and voluntary motor impairment.
AB - The present study documents the prevalence of deficits in the ability to carry out a variety of activities of daily living in early Huntington’s disease (HD), along with the associated neuropsychological and motor deficits. Eighty patients with HD were assessed with the Huntington’s Disease-Activities of Daily Living Questionnaire (HD-ADL). Sixty-seven patients also completed a comprehensive assessment of cognitive and voluntary motor functioning and chorea. The latter measures were correlated with HD-ADL total score and with most HD-ADL items, but not with those items dealing with marital and family relationship adjustment. Findings suggest that psychomotor speed and the ability to regulate attention may be particularly important determinants of everyday functioning in mild HD. Consistent with previously reported observations, this appears to be true even after accounting for individual differences in the severity of chorea and voluntary motor impairment.
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U2 - 10.1097/00005053-199303000-00008
DO - 10.1097/00005053-199303000-00008
M3 - Article
C2 - 8445379
AN - SCOPUS:0027481424
VL - 181
SP - 194
EP - 199
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
SN - 0022-3018
IS - 3
ER -