Cognitive and brain magnetic resonance imaging findings in adrenomyeloneuropathy

David Edwin, Lynn J. Speedie, Wolfgang Kohler, Sakkubai Naidu, Bernd Kruse, Hugo W. Moser

Research output: Contribution to journalArticle

Abstract

Neuropsychological functioning and brain magnetic resonance imaging (MRI) were evaluated in 84 men with adrenomyeloneuropathy (AMN). MRI was normal in 61%, the 'pure AMN' group, while 39%, the 'cerebral AMN' group, showed brain white matter abnormalities. Except for mild deficits in psychomotor speed and visual memory, neuropsychological function was normal in pure AMN. Most patients with cerebral AMN had normal IQ and language but evidenced impaired psychomotor speed, spatial cognition, memory, and executive functions. Patients with MRI evidence of very severe cerebral disease had global and language impairment as well, and deficits in all patients were highly correlated with degree of brain MRI involvement.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalAnnals of neurology
Volume40
Issue number4
DOIs
StatePublished - Oct 1 1996

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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