Cognitive and behavioral effects of cholinergic, dopaminergic, and serotonergic blockade in humans

Benedetto Vitiello, Alex Martin, James Hill, Carol Mack, Susan Molchan, Rick Martinez, Dennis L. Murphy, Trey Sunderland

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate the cognitive and behavioral effects of anticholinergic, antidopaminergic, and antiserotonergic agents given alone and in combination to normal volunteers. Twelve young male volunteers took part in this double-blind randomized, placebo-controlled, crossover study of six drug conditions, each administered on separate days [haloperidol (2 mg PO) ± scopolamine (0.5 mg IV), metergoline (4 mg PO) ± scopolamine (0.5 mg IV), placebo, and scopolamine alone (0.5 mg IV)]. Scopolamine-induced sedation (p

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalNeuropsychopharmacology
Volume16
Issue number1
DOIs
StatePublished - Jan 1997
Externally publishedYes

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Scopolamine Hydrobromide
Cholinergic Agents
Placebos
Metergoline
Serotonin Antagonists
Cholinergic Antagonists
Haloperidol
Cross-Over Studies
Volunteers
Healthy Volunteers
Pharmaceutical Preparations

Keywords

  • Cognition
  • Haloperidol
  • Metergoline
  • Scopolamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Vitiello, B., Martin, A., Hill, J., Mack, C., Molchan, S., Martinez, R., ... Sunderland, T. (1997). Cognitive and behavioral effects of cholinergic, dopaminergic, and serotonergic blockade in humans. Neuropsychopharmacology, 16(1), 15-24. https://doi.org/10.1016/S0893-133X(96)00134-0

Cognitive and behavioral effects of cholinergic, dopaminergic, and serotonergic blockade in humans. / Vitiello, Benedetto; Martin, Alex; Hill, James; Mack, Carol; Molchan, Susan; Martinez, Rick; Murphy, Dennis L.; Sunderland, Trey.

In: Neuropsychopharmacology, Vol. 16, No. 1, 01.1997, p. 15-24.

Research output: Contribution to journalArticle

Vitiello, B, Martin, A, Hill, J, Mack, C, Molchan, S, Martinez, R, Murphy, DL & Sunderland, T 1997, 'Cognitive and behavioral effects of cholinergic, dopaminergic, and serotonergic blockade in humans', Neuropsychopharmacology, vol. 16, no. 1, pp. 15-24. https://doi.org/10.1016/S0893-133X(96)00134-0
Vitiello, Benedetto ; Martin, Alex ; Hill, James ; Mack, Carol ; Molchan, Susan ; Martinez, Rick ; Murphy, Dennis L. ; Sunderland, Trey. / Cognitive and behavioral effects of cholinergic, dopaminergic, and serotonergic blockade in humans. In: Neuropsychopharmacology. 1997 ; Vol. 16, No. 1. pp. 15-24.
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