Cognitive abilities of patients with Lesch-Nyhan disease

Lowell T. Anderson, Monique Ernst, Susan V. Davis

Research output: Contribution to journalArticle

Abstract

Parents of 42 patients with Lesch-Nyhan disease completed a questionnaire systematizing caregiver observations of the subject's behavior during a wide variety of daily events. Responses were grouped in nine categories reflecting different aspects of cognitive skills. Only 1 boy appears to have any significant generalized cognitive impairment. The patients' memory for both recent and past events is excellent, their emotional life has a normal range of reactions and is appropriate; they have good concentration, are capable of abstract reasoning, have good self-awareness, and are highly social. However, they are behind in academic ability, with only 15% at grade level for math and reading. Implications for designing educational activities, parenting or caregiver strategies, and research methodology are discussed.

Original languageEnglish (US)
Pages (from-to)189-203
Number of pages15
JournalJournal of Autism and Developmental Disorders
Volume22
Issue number2
DOIs
StatePublished - Jun 1992
Externally publishedYes

Fingerprint

Lesch-Nyhan Syndrome
Aptitude
Caregivers
Parenting
Reading
Reference Values
Research Design
Parents
Education

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychology(all)

Cite this

Cognitive abilities of patients with Lesch-Nyhan disease. / Anderson, Lowell T.; Ernst, Monique; Davis, Susan V.

In: Journal of Autism and Developmental Disorders, Vol. 22, No. 2, 06.1992, p. 189-203.

Research output: Contribution to journalArticle

Anderson, Lowell T. ; Ernst, Monique ; Davis, Susan V. / Cognitive abilities of patients with Lesch-Nyhan disease. In: Journal of Autism and Developmental Disorders. 1992 ; Vol. 22, No. 2. pp. 189-203.
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