Cognition in perimenopause: The effect of transition stage

Miriam T. Weber, Leah Rubin, Pauline M. Maki

Research output: Contribution to journalArticle

Abstract

Objective: The aims of this cross-sectional study were to determine if cognitive function differs across stages of reproductive aging and to evaluate whether hormones or menopausal symptoms predict cognition in perimenopause. We hypothesized that women in late menopausal transition and early postmenopause would perform more poorly than those in the late reproductive stage on attention and verbal memory tasks, and that estradiol, depressive symptoms, anxiety symptoms, hot flashes, and sleep disturbance would predict cognitive performance on those tasks. Methods: One hundred seventeen middle-aged women enrolled in the Rochester Investigation of Cognition Across Menopause were categorized into late reproductive stage (n = 34), early menopausal transition stage (n = 28), late menopausal transition stage (n = 41), or early postmenopause stage (n = 14) according to criteria from the Stages of Reproductive Aging Workshop +10. We administered a neuropsychological battery assessing six domains of cognition, assessed menopausal symptoms, and measured serum levels of estradiol and follicle-stimulating hormone. Multivariate regressions were conducted to determine the impact of menopausal stage and symptoms on cognition. Results: Women in the first year of postmenopause performed significantly worse than women in the late reproductive and late menopausal transition stages on measures of verbal learning, verbal memory, and motor function. They also performed significantly worse than women in the late menopausal transition stage on attention/working memory tasks. Conclusions: Cognitive function does not change linearly across perimenopause. Decreases in attention/working memory, verbal learning, verbal memory, and fine motor speed may be most evident in the first year after the final menstrual period.

Original languageEnglish (US)
Pages (from-to)511-517
Number of pages7
JournalMenopause
Volume20
Issue number5
DOIs
StatePublished - May 1 2013
Externally publishedYes

Fingerprint

Perimenopause
Cognition
Postmenopause
Verbal Learning
Short-Term Memory
Estradiol
Hot Flashes
Follicle Stimulating Hormone
Menopause
Sleep
Anxiety
Cross-Sectional Studies
Hormones
Depression
Education
Serum

Keywords

  • Cognition
  • Estrogen
  • Memory
  • Menopausal transition
  • Perimenopause

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Cognition in perimenopause : The effect of transition stage. / Weber, Miriam T.; Rubin, Leah; Maki, Pauline M.

In: Menopause, Vol. 20, No. 5, 01.05.2013, p. 511-517.

Research output: Contribution to journalArticle

Weber, Miriam T. ; Rubin, Leah ; Maki, Pauline M. / Cognition in perimenopause : The effect of transition stage. In: Menopause. 2013 ; Vol. 20, No. 5. pp. 511-517.
@article{127226a3b8564eab9ecc49552afcc380,
title = "Cognition in perimenopause: The effect of transition stage",
abstract = "Objective: The aims of this cross-sectional study were to determine if cognitive function differs across stages of reproductive aging and to evaluate whether hormones or menopausal symptoms predict cognition in perimenopause. We hypothesized that women in late menopausal transition and early postmenopause would perform more poorly than those in the late reproductive stage on attention and verbal memory tasks, and that estradiol, depressive symptoms, anxiety symptoms, hot flashes, and sleep disturbance would predict cognitive performance on those tasks. Methods: One hundred seventeen middle-aged women enrolled in the Rochester Investigation of Cognition Across Menopause were categorized into late reproductive stage (n = 34), early menopausal transition stage (n = 28), late menopausal transition stage (n = 41), or early postmenopause stage (n = 14) according to criteria from the Stages of Reproductive Aging Workshop +10. We administered a neuropsychological battery assessing six domains of cognition, assessed menopausal symptoms, and measured serum levels of estradiol and follicle-stimulating hormone. Multivariate regressions were conducted to determine the impact of menopausal stage and symptoms on cognition. Results: Women in the first year of postmenopause performed significantly worse than women in the late reproductive and late menopausal transition stages on measures of verbal learning, verbal memory, and motor function. They also performed significantly worse than women in the late menopausal transition stage on attention/working memory tasks. Conclusions: Cognitive function does not change linearly across perimenopause. Decreases in attention/working memory, verbal learning, verbal memory, and fine motor speed may be most evident in the first year after the final menstrual period.",
keywords = "Cognition, Estrogen, Memory, Menopausal transition, Perimenopause",
author = "Weber, {Miriam T.} and Leah Rubin and Maki, {Pauline M.}",
year = "2013",
month = "5",
day = "1",
doi = "10.1097/gme.0b013e31827655e5",
language = "English (US)",
volume = "20",
pages = "511--517",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Cognition in perimenopause

T2 - The effect of transition stage

AU - Weber, Miriam T.

AU - Rubin, Leah

AU - Maki, Pauline M.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Objective: The aims of this cross-sectional study were to determine if cognitive function differs across stages of reproductive aging and to evaluate whether hormones or menopausal symptoms predict cognition in perimenopause. We hypothesized that women in late menopausal transition and early postmenopause would perform more poorly than those in the late reproductive stage on attention and verbal memory tasks, and that estradiol, depressive symptoms, anxiety symptoms, hot flashes, and sleep disturbance would predict cognitive performance on those tasks. Methods: One hundred seventeen middle-aged women enrolled in the Rochester Investigation of Cognition Across Menopause were categorized into late reproductive stage (n = 34), early menopausal transition stage (n = 28), late menopausal transition stage (n = 41), or early postmenopause stage (n = 14) according to criteria from the Stages of Reproductive Aging Workshop +10. We administered a neuropsychological battery assessing six domains of cognition, assessed menopausal symptoms, and measured serum levels of estradiol and follicle-stimulating hormone. Multivariate regressions were conducted to determine the impact of menopausal stage and symptoms on cognition. Results: Women in the first year of postmenopause performed significantly worse than women in the late reproductive and late menopausal transition stages on measures of verbal learning, verbal memory, and motor function. They also performed significantly worse than women in the late menopausal transition stage on attention/working memory tasks. Conclusions: Cognitive function does not change linearly across perimenopause. Decreases in attention/working memory, verbal learning, verbal memory, and fine motor speed may be most evident in the first year after the final menstrual period.

AB - Objective: The aims of this cross-sectional study were to determine if cognitive function differs across stages of reproductive aging and to evaluate whether hormones or menopausal symptoms predict cognition in perimenopause. We hypothesized that women in late menopausal transition and early postmenopause would perform more poorly than those in the late reproductive stage on attention and verbal memory tasks, and that estradiol, depressive symptoms, anxiety symptoms, hot flashes, and sleep disturbance would predict cognitive performance on those tasks. Methods: One hundred seventeen middle-aged women enrolled in the Rochester Investigation of Cognition Across Menopause were categorized into late reproductive stage (n = 34), early menopausal transition stage (n = 28), late menopausal transition stage (n = 41), or early postmenopause stage (n = 14) according to criteria from the Stages of Reproductive Aging Workshop +10. We administered a neuropsychological battery assessing six domains of cognition, assessed menopausal symptoms, and measured serum levels of estradiol and follicle-stimulating hormone. Multivariate regressions were conducted to determine the impact of menopausal stage and symptoms on cognition. Results: Women in the first year of postmenopause performed significantly worse than women in the late reproductive and late menopausal transition stages on measures of verbal learning, verbal memory, and motor function. They also performed significantly worse than women in the late menopausal transition stage on attention/working memory tasks. Conclusions: Cognitive function does not change linearly across perimenopause. Decreases in attention/working memory, verbal learning, verbal memory, and fine motor speed may be most evident in the first year after the final menstrual period.

KW - Cognition

KW - Estrogen

KW - Memory

KW - Menopausal transition

KW - Perimenopause

UR - http://www.scopus.com/inward/record.url?scp=84879248966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879248966&partnerID=8YFLogxK

U2 - 10.1097/gme.0b013e31827655e5

DO - 10.1097/gme.0b013e31827655e5

M3 - Article

C2 - 23615642

AN - SCOPUS:84879248966

VL - 20

SP - 511

EP - 517

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 5

ER -