Cognition and Hippocampal Systems in Aging: Animal Models

Michela Gallagher, Alan H. Nagahara, Rebecca D. Burwell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter considers how research using laboratory animals contributes to our understanding of aging in mammals. It deals first with how such studies help to address some of the more vexing questions about the nature of aging that have arisen in research with humans. It shows that animal models of cognitive aging can provide a framework for research to address more fundamental questions about the mechanisms through which the aging process is regulated and expressed in neural systems. Together with the results of studies on the septo-hippocampal projection, it also becomes apparent that aging has an impact on different neural elements within this circuitry. Studies have also shown significant neurobiological changes within the hippocampus proper that are correlated with cognitive decline during aging.

Original languageEnglish (US)
Title of host publicationBrain and Memory
Subtitle of host publicationModulation and Mediation of Neuroplasticity
PublisherOxford University Press
ISBN (Electronic)9780199847877
ISBN (Print)9780195082944
DOIs
StatePublished - Mar 22 2012
Externally publishedYes

Keywords

  • Aging
  • Animal models
  • Cognitive decline
  • Hippocampus
  • Neural systems
  • Septo-hippocampal projection

ASJC Scopus subject areas

  • Psychology(all)

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