Cognition and Hippocampal Systems in Aging: Animal Models

Michela Gallagher; Alan H. Nagahara; Rebecca D. Burwell

doi:10.1093/acprof:oso/9780195082944.003.0006

Cognition and Hippocampal Systems in Aging: Animal Models

Michela Gallagher, Alan H. Nagahara, Rebecca D. Burwell

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter considers how research using laboratory animals contributes to our understanding of aging in mammals. It deals first with how such studies help to address some of the more vexing questions about the nature of aging that have arisen in research with humans. It shows that animal models of cognitive aging can provide a framework for research to address more fundamental questions about the mechanisms through which the aging process is regulated and expressed in neural systems. Together with the results of studies on the septo-hippocampal projection, it also becomes apparent that aging has an impact on different neural elements within this circuitry. Studies have also shown significant neurobiological changes within the hippocampus proper that are correlated with cognitive decline during aging.

Original language	English (US)
Title of host publication	Brain and Memory
Subtitle of host publication	Modulation and Mediation of Neuroplasticity
Publisher	Oxford University Press
ISBN (Electronic)	9780199847877
ISBN (Print)	9780195082944
DOIs	https://doi.org/10.1093/acprof:oso/9780195082944.003.0006
State	Published - Mar 22 2012
Externally published	Yes

Keywords

Aging
Animal models
Cognitive decline
Hippocampus
Neural systems
Septo-hippocampal projection

ASJC Scopus subject areas

Psychology(all)

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10.1093/acprof:oso/9780195082944.003.0006

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abstract = "This chapter considers how research using laboratory animals contributes to our understanding of aging in mammals. It deals first with how such studies help to address some of the more vexing questions about the nature of aging that have arisen in research with humans. It shows that animal models of cognitive aging can provide a framework for research to address more fundamental questions about the mechanisms through which the aging process is regulated and expressed in neural systems. Together with the results of studies on the septo-hippocampal projection, it also becomes apparent that aging has an impact on different neural elements within this circuitry. Studies have also shown significant neurobiological changes within the hippocampus proper that are correlated with cognitive decline during aging.",

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AU - Burwell, Rebecca D.

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AB - This chapter considers how research using laboratory animals contributes to our understanding of aging in mammals. It deals first with how such studies help to address some of the more vexing questions about the nature of aging that have arisen in research with humans. It shows that animal models of cognitive aging can provide a framework for research to address more fundamental questions about the mechanisms through which the aging process is regulated and expressed in neural systems. Together with the results of studies on the septo-hippocampal projection, it also becomes apparent that aging has an impact on different neural elements within this circuitry. Studies have also shown significant neurobiological changes within the hippocampus proper that are correlated with cognitive decline during aging.

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KW - Cognitive decline

KW - Hippocampus

KW - Neural systems

KW - Septo-hippocampal projection

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Cognition and Hippocampal Systems in Aging: Animal Models

Abstract

Keywords

ASJC Scopus subject areas

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