Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18 (AV-45) positron emission tomography

Paul B Rosenberg, Dean Foster Wong, S. L. Edell, J. S. Ross, A. D. Joshi, James R Brasic, Yun Zhou, V. Raymont, A. Kumar, H. T. Ravert, Robert F Dannals, M. J. Pontecorvo, D. M. Skovronsky, Constantine G Lyketsos

Research output: Contribution to journalArticle

Abstract

Objective: To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([ 18F]-AV-45) and cognitive performance in a pilot study. Design: Cross-sectional comparison of [18F]-AV- 45 in AD patients versus controls. Setting: Three specialty memory clinics. Participants: Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants. Measurements: Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [ 18F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency. Results: Greater [18F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [18F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment. Conclusion: [ 18F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.

Original languageEnglish (US)
Pages (from-to)272-278
Number of pages7
JournalAmerican Journal of Geriatric Psychiatry
Volume21
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Amyloid
Positron-Emission Tomography
Cognition
Alzheimer Disease
Healthy Volunteers
National Institute of Neurological Disorders and Stroke
Parietal Lobe
Gyrus Cinguli
Brain
florbetapir
Short-Term Memory
Intravenous Administration

Keywords

  • 18-flourine
  • Alzheimer
  • Amyloid
  • Cognition
  • PET tracer
  • Positron emission tomography
  • Standardized uptake value ratios

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18 (AV-45) positron emission tomography. / Rosenberg, Paul B; Wong, Dean Foster; Edell, S. L.; Ross, J. S.; Joshi, A. D.; Brasic, James R; Zhou, Yun; Raymont, V.; Kumar, A.; Ravert, H. T.; Dannals, Robert F; Pontecorvo, M. J.; Skovronsky, D. M.; Lyketsos, Constantine G.

In: American Journal of Geriatric Psychiatry, Vol. 21, No. 3, 03.2013, p. 272-278.

Research output: Contribution to journalArticle

Rosenberg, Paul B ; Wong, Dean Foster ; Edell, S. L. ; Ross, J. S. ; Joshi, A. D. ; Brasic, James R ; Zhou, Yun ; Raymont, V. ; Kumar, A. ; Ravert, H. T. ; Dannals, Robert F ; Pontecorvo, M. J. ; Skovronsky, D. M. ; Lyketsos, Constantine G. / Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18 (AV-45) positron emission tomography. In: American Journal of Geriatric Psychiatry. 2013 ; Vol. 21, No. 3. pp. 272-278.
@article{f0c0a23d239f49b08e90d638ed4cf5f6,
title = "Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18 (AV-45) positron emission tomography",
abstract = "Objective: To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([ 18F]-AV-45) and cognitive performance in a pilot study. Design: Cross-sectional comparison of [18F]-AV- 45 in AD patients versus controls. Setting: Three specialty memory clinics. Participants: Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants. Measurements: Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [ 18F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency. Results: Greater [18F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [18F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment. Conclusion: [ 18F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.",
keywords = "18-flourine, Alzheimer, Amyloid, Cognition, PET tracer, Positron emission tomography, Standardized uptake value ratios",
author = "Rosenberg, {Paul B} and Wong, {Dean Foster} and Edell, {S. L.} and Ross, {J. S.} and Joshi, {A. D.} and Brasic, {James R} and Yun Zhou and V. Raymont and A. Kumar and Ravert, {H. T.} and Dannals, {Robert F} and Pontecorvo, {M. J.} and Skovronsky, {D. M.} and Lyketsos, {Constantine G}",
year = "2013",
month = "3",
doi = "10.1016/j.jagp.2012.11.016",
language = "English (US)",
volume = "21",
pages = "272--278",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18 (AV-45) positron emission tomography

AU - Rosenberg, Paul B

AU - Wong, Dean Foster

AU - Edell, S. L.

AU - Ross, J. S.

AU - Joshi, A. D.

AU - Brasic, James R

AU - Zhou, Yun

AU - Raymont, V.

AU - Kumar, A.

AU - Ravert, H. T.

AU - Dannals, Robert F

AU - Pontecorvo, M. J.

AU - Skovronsky, D. M.

AU - Lyketsos, Constantine G

PY - 2013/3

Y1 - 2013/3

N2 - Objective: To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([ 18F]-AV-45) and cognitive performance in a pilot study. Design: Cross-sectional comparison of [18F]-AV- 45 in AD patients versus controls. Setting: Three specialty memory clinics. Participants: Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants. Measurements: Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [ 18F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency. Results: Greater [18F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [18F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment. Conclusion: [ 18F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.

AB - Objective: To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([ 18F]-AV-45) and cognitive performance in a pilot study. Design: Cross-sectional comparison of [18F]-AV- 45 in AD patients versus controls. Setting: Three specialty memory clinics. Participants: Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants. Measurements: Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [ 18F]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency. Results: Greater [18F]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [18F]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment. Conclusion: [ 18F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.

KW - 18-flourine

KW - Alzheimer

KW - Amyloid

KW - Cognition

KW - PET tracer

KW - Positron emission tomography

KW - Standardized uptake value ratios

UR - http://www.scopus.com/inward/record.url?scp=84875449522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875449522&partnerID=8YFLogxK

U2 - 10.1016/j.jagp.2012.11.016

DO - 10.1016/j.jagp.2012.11.016

M3 - Article

VL - 21

SP - 272

EP - 278

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

SN - 1064-7481

IS - 3

ER -