Cogelation of Hydrolyzable Cross-Linkers and Poly(ethylene oxide) Dimethacrylate and Their Use as Controlled Release Vehicles

Jennifer Elisseeff, Winnette McIntosh, Kristi Anseth, Robert Langer

Research output: Contribution to journalArticlepeer-review

Abstract

Small molecular weight crosslinking agents containing hydrolyzable bonds were photopolymerized with poly(ethylene oxide) in order to decrease the pore size of the gels. The resulting cogels decreased in equilibrium swelling volume (pore size) as the concentration of crosslinker increased. The initial release profile of the model protein albumin showed a decreased burst in the presence of small molecular weight crosslinkers in the photopolymerized hydrogels.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalACS Symposium Series
Volume728
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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