Coffee Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study

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Abstract

Background: Moderate coffee consumption has been suggested to be associated with lower risk for chronic conditions such as diabetes, a major precursor to chronic kidney disease (CKD). However, the association between coffee and CKD has not been fully established. Study Design: Prospective cohort study. Setting & Participants: 14,209 participants aged 45 to 64 years from the Atherosclerosis Risk in Communities (ARIC) Study. Predictors: Coffee consumption (cups per day) was assessed at visits 1 (1987-1989) and 3 (1993-1995) using food frequency questionnaires. Outcomes: Incident CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 accompanied by ≥25% estimated glomerular filtration rate decline, CKD-related hospitalization or death, or end-stage renal disease. Results: There were 3,845 cases of incident CKD over a median of 24 years of follow-up. Men, whites, current smokers, and participants without comorbid conditions were more likely to consume higher amounts of coffee per day. After adjustment for demographic, clinical, and dietary factors, higher categories of coffee consumption were associated with lower risk for incident CKD compared with those who never consumed coffee (HR for <1 cup per day, 0.90 [95% CI, 0.82-0.99]; 1-<2 cups per day, 0.90 [95% CI, 0.82-0.99]; 2-<3 cups per day, 0.87 [95% CI, 0.77-0.97]; and ≥3 cups per day, 0.84 [95% CI, 0.75-0.94]). In continuous analysis, for each additional cup of coffee consumed per day, risk for incident CKD was lower by 3% (HR, 0.97; 95% CI, 0.95-0.99; P < 0.001). Limitations: Self-reported coffee consumption and observational design. Conclusions: Participants who drank higher amounts of coffee had lower risk for incident CKD after adjusting for covariates. Coffee consumers may not be at adverse risk for kidney disease.

Original languageEnglish (US)
JournalAmerican Journal of Kidney Diseases
DOIs
StateAccepted/In press - Jan 1 2018

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Coffee
Kidney Diseases
Atherosclerosis
Chronic Renal Insufficiency
Glomerular Filtration Rate
Chronic Kidney Failure
Hospitalization
Cohort Studies
Demography
Prospective Studies
Food

Keywords

  • beverages
  • chronic kidney disease (CKD)
  • Coffee
  • diet
  • incident CKD
  • kidney failure
  • modifiable risk factor

ASJC Scopus subject areas

  • Nephrology

Cite this

@article{08a97926035e42c5934d7c2505c4a7d5,
title = "Coffee Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study",
abstract = "Background: Moderate coffee consumption has been suggested to be associated with lower risk for chronic conditions such as diabetes, a major precursor to chronic kidney disease (CKD). However, the association between coffee and CKD has not been fully established. Study Design: Prospective cohort study. Setting & Participants: 14,209 participants aged 45 to 64 years from the Atherosclerosis Risk in Communities (ARIC) Study. Predictors: Coffee consumption (cups per day) was assessed at visits 1 (1987-1989) and 3 (1993-1995) using food frequency questionnaires. Outcomes: Incident CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 accompanied by ≥25{\%} estimated glomerular filtration rate decline, CKD-related hospitalization or death, or end-stage renal disease. Results: There were 3,845 cases of incident CKD over a median of 24 years of follow-up. Men, whites, current smokers, and participants without comorbid conditions were more likely to consume higher amounts of coffee per day. After adjustment for demographic, clinical, and dietary factors, higher categories of coffee consumption were associated with lower risk for incident CKD compared with those who never consumed coffee (HR for <1 cup per day, 0.90 [95{\%} CI, 0.82-0.99]; 1-<2 cups per day, 0.90 [95{\%} CI, 0.82-0.99]; 2-<3 cups per day, 0.87 [95{\%} CI, 0.77-0.97]; and ≥3 cups per day, 0.84 [95{\%} CI, 0.75-0.94]). In continuous analysis, for each additional cup of coffee consumed per day, risk for incident CKD was lower by 3{\%} (HR, 0.97; 95{\%} CI, 0.95-0.99; P < 0.001). Limitations: Self-reported coffee consumption and observational design. Conclusions: Participants who drank higher amounts of coffee had lower risk for incident CKD after adjusting for covariates. Coffee consumers may not be at adverse risk for kidney disease.",
keywords = "beverages, chronic kidney disease (CKD), Coffee, diet, incident CKD, kidney failure, modifiable risk factor",
author = "Hu, {Emily A.} and Elizabeth Selvin and Morgan Grams and Steffen, {Lyn M.} and Josef Coresh and Casey Rebholz",
year = "2018",
month = "1",
day = "1",
doi = "10.1053/j.ajkd.2018.01.030",
language = "English (US)",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Coffee Consumption and Incident Kidney Disease

T2 - Results From the Atherosclerosis Risk in Communities (ARIC) Study

AU - Hu, Emily A.

AU - Selvin, Elizabeth

AU - Grams, Morgan

AU - Steffen, Lyn M.

AU - Coresh, Josef

AU - Rebholz, Casey

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Moderate coffee consumption has been suggested to be associated with lower risk for chronic conditions such as diabetes, a major precursor to chronic kidney disease (CKD). However, the association between coffee and CKD has not been fully established. Study Design: Prospective cohort study. Setting & Participants: 14,209 participants aged 45 to 64 years from the Atherosclerosis Risk in Communities (ARIC) Study. Predictors: Coffee consumption (cups per day) was assessed at visits 1 (1987-1989) and 3 (1993-1995) using food frequency questionnaires. Outcomes: Incident CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 accompanied by ≥25% estimated glomerular filtration rate decline, CKD-related hospitalization or death, or end-stage renal disease. Results: There were 3,845 cases of incident CKD over a median of 24 years of follow-up. Men, whites, current smokers, and participants without comorbid conditions were more likely to consume higher amounts of coffee per day. After adjustment for demographic, clinical, and dietary factors, higher categories of coffee consumption were associated with lower risk for incident CKD compared with those who never consumed coffee (HR for <1 cup per day, 0.90 [95% CI, 0.82-0.99]; 1-<2 cups per day, 0.90 [95% CI, 0.82-0.99]; 2-<3 cups per day, 0.87 [95% CI, 0.77-0.97]; and ≥3 cups per day, 0.84 [95% CI, 0.75-0.94]). In continuous analysis, for each additional cup of coffee consumed per day, risk for incident CKD was lower by 3% (HR, 0.97; 95% CI, 0.95-0.99; P < 0.001). Limitations: Self-reported coffee consumption and observational design. Conclusions: Participants who drank higher amounts of coffee had lower risk for incident CKD after adjusting for covariates. Coffee consumers may not be at adverse risk for kidney disease.

AB - Background: Moderate coffee consumption has been suggested to be associated with lower risk for chronic conditions such as diabetes, a major precursor to chronic kidney disease (CKD). However, the association between coffee and CKD has not been fully established. Study Design: Prospective cohort study. Setting & Participants: 14,209 participants aged 45 to 64 years from the Atherosclerosis Risk in Communities (ARIC) Study. Predictors: Coffee consumption (cups per day) was assessed at visits 1 (1987-1989) and 3 (1993-1995) using food frequency questionnaires. Outcomes: Incident CKD defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 accompanied by ≥25% estimated glomerular filtration rate decline, CKD-related hospitalization or death, or end-stage renal disease. Results: There were 3,845 cases of incident CKD over a median of 24 years of follow-up. Men, whites, current smokers, and participants without comorbid conditions were more likely to consume higher amounts of coffee per day. After adjustment for demographic, clinical, and dietary factors, higher categories of coffee consumption were associated with lower risk for incident CKD compared with those who never consumed coffee (HR for <1 cup per day, 0.90 [95% CI, 0.82-0.99]; 1-<2 cups per day, 0.90 [95% CI, 0.82-0.99]; 2-<3 cups per day, 0.87 [95% CI, 0.77-0.97]; and ≥3 cups per day, 0.84 [95% CI, 0.75-0.94]). In continuous analysis, for each additional cup of coffee consumed per day, risk for incident CKD was lower by 3% (HR, 0.97; 95% CI, 0.95-0.99; P < 0.001). Limitations: Self-reported coffee consumption and observational design. Conclusions: Participants who drank higher amounts of coffee had lower risk for incident CKD after adjusting for covariates. Coffee consumers may not be at adverse risk for kidney disease.

KW - beverages

KW - chronic kidney disease (CKD)

KW - Coffee

KW - diet

KW - incident CKD

KW - kidney failure

KW - modifiable risk factor

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