Coexistence of gonadoblastoma and dysgerminoma in a dysgenetic gonad on touch preparation: A case report

Zahra Maleki, Meredith Loveless, Mostafa Fraig

Research output: Contribution to journalArticle

Abstract

Swyer syndrome is known as pure gonadal dysgenesis. Individuals with Swyer syndrome are phenotypically female with unambiguously female genital appearance at birth, and normal Mullerian structures. The condition usually first becomes apparent in adolescence with delayed puberty and amenorrhea due to the fact that the gonads have no hormonal or reproductive potential. These individuals are characterized by 46XY karyotype, primary amenorrhea, tall stature, female external genitalia and normal but hypoestrogenised vagina and cervix. A high incidence of gonadoblastoma and germ cell malignancies has been reported in dysgenetic gonads, and therefore, the current practice is to proceed to a gonadectomy once the diagnosis is made. Herein, we report a case of gonadoblastoma and dysgerminoma diagnosed on touch preparation in a dysgenetic gonad of a 16-year-old patient with Swyer syndrome.

Original languageEnglish (US)
Pages (from-to)42-44
Number of pages3
JournalDiagnostic Cytopathology
Volume39
Issue number1
DOIs
StatePublished - Jan 2011

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46,XY Gonadal Dysgenesis
Gonadoblastoma
Dysgerminoma
Touch
Gonads
Amenorrhea
Delayed Puberty
Gonadal Dysgenesis
Female Genitalia
Vagina
Karyotype
Germ Cells
Cervix Uteri
Parturition
Incidence
Neoplasms

Keywords

  • dysgerminoma
  • gonadoblastoma
  • Swyer syndrome
  • touch preparation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Coexistence of gonadoblastoma and dysgerminoma in a dysgenetic gonad on touch preparation : A case report. / Maleki, Zahra; Loveless, Meredith; Fraig, Mostafa.

In: Diagnostic Cytopathology, Vol. 39, No. 1, 01.2011, p. 42-44.

Research output: Contribution to journalArticle

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