Cockroach allergen exposure and sensitization in suburban middle-class children with asthma

Elizabeth C. Matsui, Robert A Wood, Cynthia S Rand, Sukon Kanchanaraksa, Lee J Swartz, Jean Curtin-Brosnan, Peyton A. Eggleston

Research output: Contribution to journalArticle

Abstract

Background: Exposure to cockroach allergen is prevalent in inner-city homes and is associated with an increased risk of cockroach sensitization. Objective: We sought to determine the prevalence of cockroach allergen exposure in suburban middle-class homes and to study its relationship to cockroach sensitization. Methods: Children with asthma, 6 to 17 years of age, were recruited from 3 pediatric practices located in counties surrounding Baltimore city and from 1 practice located within Baltimore city limits. Participants underwent skin prick testing and completed baseline questionnaires. In addition, their homes were inspected, and settled dust samples were collected for allergen analysis. Results: Forty-one percent of the total study population (n = 339) had kitchen Bla g 1 levels of greater than 1 U/g. Forty-nine percent were white, 53% had annual incomes of greater than $50,000, and 48% of mothers had college degrees. Seventy-seven percent of the study population resided in a suburban or rural location, and 30% of kitchens in these homes had Bla g 1 levels of greater than 1 U/g. Among the suburban-rural subgroup, 21% were sensitized to cockroach compared with 35% of the city group. In multivariate analysis, exposure to kitchen Bla g 1 levels of greater than 1 U/g was associated with cockroach sensitization for both the total study population (odds ratio, 2.29; 95% CI, 1.28-4.11) and the suburban-rural subgroup (odds ratio, 2.37; 95% CI, 1.23-4.57). Conclusions: Cockroach allergen exposure might be more common in suburban middle-class homes of asthmatic children than previously thought. Moreover, the data suggest that low-level cockroach exposure is a risk factor for cockroach sensitization.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume112
Issue number1
DOIs
StatePublished - Jul 1 2003

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Cockroaches
Allergens
Asthma
Baltimore
Odds Ratio
Population
Dust
Multivariate Analysis
Mothers
Pediatrics
Skin

Keywords

  • Allergen exposure
  • Childhood asthma
  • Cockroach allergen
  • Cockroach sensitization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cockroach allergen exposure and sensitization in suburban middle-class children with asthma. / Matsui, Elizabeth C.; Wood, Robert A; Rand, Cynthia S; Kanchanaraksa, Sukon; Swartz, Lee J; Curtin-Brosnan, Jean; Eggleston, Peyton A.

In: The Journal of Allergy and Clinical Immunology, Vol. 112, No. 1, 01.07.2003, p. 87-92.

Research output: Contribution to journalArticle

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abstract = "Background: Exposure to cockroach allergen is prevalent in inner-city homes and is associated with an increased risk of cockroach sensitization. Objective: We sought to determine the prevalence of cockroach allergen exposure in suburban middle-class homes and to study its relationship to cockroach sensitization. Methods: Children with asthma, 6 to 17 years of age, were recruited from 3 pediatric practices located in counties surrounding Baltimore city and from 1 practice located within Baltimore city limits. Participants underwent skin prick testing and completed baseline questionnaires. In addition, their homes were inspected, and settled dust samples were collected for allergen analysis. Results: Forty-one percent of the total study population (n = 339) had kitchen Bla g 1 levels of greater than 1 U/g. Forty-nine percent were white, 53{\%} had annual incomes of greater than $50,000, and 48{\%} of mothers had college degrees. Seventy-seven percent of the study population resided in a suburban or rural location, and 30{\%} of kitchens in these homes had Bla g 1 levels of greater than 1 U/g. Among the suburban-rural subgroup, 21{\%} were sensitized to cockroach compared with 35{\%} of the city group. In multivariate analysis, exposure to kitchen Bla g 1 levels of greater than 1 U/g was associated with cockroach sensitization for both the total study population (odds ratio, 2.29; 95{\%} CI, 1.28-4.11) and the suburban-rural subgroup (odds ratio, 2.37; 95{\%} CI, 1.23-4.57). Conclusions: Cockroach allergen exposure might be more common in suburban middle-class homes of asthmatic children than previously thought. Moreover, the data suggest that low-level cockroach exposure is a risk factor for cockroach sensitization.",
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