Cochlear function among HIV-seropositive and HIV-seronegative men and women

Peter Torre, Howard J. Hoffman, Gayle Springer, Christopher Cox, Mary Young, Joseph Bernard Margolick, Michael Plankey

Research output: Contribution to journalArticle

Abstract

Objectives: There is limited research about cochlear function in adults who are human immunodeficiency virus (HIV) positive (+). The aim of the present study was to collect measures of cochlear function in a large sample of adults with, or at risk for, HIV infection, to evaluate associations between HIV status, HIV treatment, and cochlear function. Design: Distortion product otoacoustic emissions (DPOAEs) were used to evaluate cochlear function in 506 participants; 329 men, 150 of whom were HIV+, and 177 women, 136 of whom were HIV+. DPOAEs were measured at frequencies 1000, 2000, 3000, 4000, and 6000 Hz. A DPOAE nonresponse (NR) was defined as an absolute DPOAE level less than -15 dB SPL or a difference between the absolute DPOAE level and the background noise level less than 6 dB. The total number of NRs was calculated for each ear. The associations of demographic variables, HIV status, and HIV treatment with number of NRs were evaluated with univariate and multivariate ordinal regression models. Results: There was a statistically significant increase in the odds of higher numbers of NRs with age, being male, and being non-Black, but not with HIV status. Among HIV+ participants, there were no statistically significant associations of the HIV disease status or treatment variables with higher number of NRs. Conclusion: The authors found no evidence of impaired cochlear function by HIV disease status or highly active antiretroviral therapy-treated HIV infection in this cross-sectional study.

Original languageEnglish (US)
Pages (from-to)56-62
Number of pages7
JournalEar and Hearing
Volume35
Issue number1
DOIs
StatePublished - Jan 2014

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Cochlea
HIV
Virus Diseases
Highly Active Antiretroviral Therapy
Ear
Noise
Therapeutics
Cross-Sectional Studies
Demography

Keywords

  • Cochlear function
  • Multicenter AIDS Cohort Study
  • Women's Interagency HIV Study

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing

Cite this

Cochlear function among HIV-seropositive and HIV-seronegative men and women. / Torre, Peter; Hoffman, Howard J.; Springer, Gayle; Cox, Christopher; Young, Mary; Margolick, Joseph Bernard; Plankey, Michael.

In: Ear and Hearing, Vol. 35, No. 1, 01.2014, p. 56-62.

Research output: Contribution to journalArticle

Torre, Peter ; Hoffman, Howard J. ; Springer, Gayle ; Cox, Christopher ; Young, Mary ; Margolick, Joseph Bernard ; Plankey, Michael. / Cochlear function among HIV-seropositive and HIV-seronegative men and women. In: Ear and Hearing. 2014 ; Vol. 35, No. 1. pp. 56-62.
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